FBXO10 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FBXO10 at single-cell level.

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0042981Biological processregulation of apoptotic process
GO_0000151Cellular componentubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXO10
Protein nameF-box protein 10
F-box only protein 10
SynonymsPRMT11
FBX10
DescriptionFUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation . Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling . .

AccessionsJ3KN78
F5GXN9
ENST00000432825.7 [Q9UK96-1]
ENST00000541607.1
ENST00000276960.7
Q9UK96