MFN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905461Biological processpositive regulation of vascular associated smooth muscle cell apoptotic process
GO_0006986Biological processresponse to unfolded protein
GO_0048593Biological processcamera-type eye morphogenesis
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0007006Biological processmitochondrial membrane organization
GO_0008053Biological processmitochondrial fusion
GO_0061734Biological processparkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO_0046580Biological processnegative regulation of Ras protein signal transduction
GO_0048662Biological processnegative regulation of smooth muscle cell proliferation
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0051646Biological processmitochondrion localization
GO_0006915Biological processapoptotic process
GO_0009060Biological processaerobic respiration
GO_0006626Biological processprotein targeting to mitochondrion
GO_0001825Biological processblastocyst formation
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005741Cellular componentmitochondrial outer membrane
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameMFN2
Protein nameMitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2)
Mitofusin 2
SynonymsKIAA0214
CPRP1
DescriptionFUNCTION: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion . Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events . Overexpression induces the formation of mitochondrial networks . Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) . Is required for PRKN recruitment to dysfunctional mitochondria . Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). .

AccessionsO95140
ENST00000676369.1
ENST00000674817.1 [O95140-1]
A0A6Q8PFT5
ENST00000444836.5 [O95140-1]
ENST00000235329.10 [O95140-1]
Q5JXC5
ENST00000674910.1 [O95140-1]
ENST00000412236.2
ENST00000675231.1 [O95140-1]
ENST00000676426.1
A0A6Q8PH07
ENST00000675053.1 [O95140-1]
A0A6Q8PGV8
A0A6Q8PGA3
ENST00000675113.1 [O95140-1]
ENST00000674658.1
A0A6Q8PFJ4
ENST00000675987.1
ENST00000497302.1
ENST00000675512.1
ENST00000675919.1 [O95140-1]
ENST00000675298.1
A0A6Q8PGS9
ENST00000675817.1
ENST00000675530.1
A0A6Q8PGR2
ENST00000674548.1 [O95140-1]
ENST00000676293.1 [O95140-1]
ENST00000675781.1