OGT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0007584Biological processresponse to nutrient
GO_1902455Biological processnegative regulation of stem cell population maintenance
GO_0071333Biological processcellular response to glucose stimulus
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0030097Biological processhemopoiesis
GO_0035020Biological processregulation of Rac protein signal transduction
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0045862Biological processpositive regulation of proteolysis
GO_0000432Biological processpositive regulation of transcription from RNA polymerase II promoter by glucose
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0060544Biological processregulation of necroptotic process
GO_0032868Biological processresponse to insulin
GO_0016485Biological processprotein processing
GO_0046889Biological processpositive regulation of lipid biosynthetic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006110Biological processregulation of glycolytic process
GO_0006111Biological processregulation of gluconeogenesis
GO_0032922Biological processcircadian regulation of gene expression
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0051963Biological processregulation of synapse assembly
GO_0006493Biological processprotein O-linked glycosylation
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0045727Biological processpositive regulation of translation
GO_0006915Biological processapoptotic process
GO_0030336Biological processnegative regulation of cell migration
GO_0000423Biological processmitophagy
GO_0098696Biological processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0046626Biological processregulation of insulin receptor signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0098978Cellular componentglutamatergic synapse
GO_0017122Cellular componentprotein N-acetylglucosaminyltransferase complex
GO_0044545Cellular componentNSL complex
GO_0005886Cellular componentplasma membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0070822Cellular componentSin3-type complex
GO_0005829Cellular componentcytosol
GO_0042995Cellular componentcell projection
GO_0000123Cellular componenthistone acetyltransferase complex
GO_0005634Cellular componentnucleus
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0097363Molecular functionprotein O-acetylglucosaminyltransferase activity
GO_0008375Molecular functionacetylglucosaminyltransferase activity
GO_0031490Molecular functionchromatin DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameOGT
Protein nameO-linked N-acetylglucosamine (GlcNAc) transferase (cDNA FLJ61388, highly similar to UDP-N-acetylglucosamine--peptideN-acetylglucosaminyltransferase 110 kDa subunit)
O-linked N-acetylglucosamine (GlcNAc) transferase
O-linked N-acetylglucosamine (GlcNAc) transferase (cDNA: FLJ23071 fis, clone LNG05694)
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT)
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit)
SynonymshCG_19962
DescriptionFUNCTION: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) . Glycosylates a large and diverse number of proteins including histone H2B, AKT1, AMPK, ATG4B, CAPRIN1, EZH2, FNIP1, KRT7, LMNA, LMNB1, LMNB2, RPTOR, HOXA1, PFKL, KMT2E/MLL5, MAPT/TAU, TET2, RBL2, RET, NOD2 and HCFC1 . Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing . Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling (By similarity). Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity . Plays a key role in chromatin structure by mediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) . As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues . O-GlcNAcylation of 'Ser-75' of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex . Stabilizes KMT2E/MLL5 by mediating its glycosylation, thereby preventing KMT2E/MLL5 ubiquitination . Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver (By similarity). Stabilizes clock proteins BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation (By similarity). Promotes the CLOCK-BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2. O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity . Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 . Regulates mitochondrial motility in neurons by mediating glycosylation of TRAK1 (By similarity). Promotes autophagy by mediating O-glycosylation of ATG4B . Acts as a regulator of mTORC1 signaling by mediating O-glycosylation of RPTOR and FNIP1: O-GlcNAcylation of RPTOR in response to glucose sufficiency promotes activation of the mTORC1 complex . .; FUNCTION: [Isoform 2]: The mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line. .; FUNCTION: [Isoform 4]: Has N-acetylglucosaminyltransferase activity: glycosylates proteins, such as HNRNPU, NEUROD1, NUP62 and PDCD6IP . Displays specific substrate selectivity compared to other isoforms . .

AccessionsENST00000699782.1
ENST00000699749.1
ENST00000444774.3
A0A8V8TP98
A0A8V8TQJ1
C9JZL3
Q548W1
ENST00000373701.7 [O15294-3]
A0A8V8TP17
ENST00000699779.1
A0A8V8TPA3
ENST00000699784.1
ENST00000699781.1
ENST00000699780.1
A0A8V8TQ37
ENST00000699785.1
O15294
ENST00000699750.1
A0A8V8TNT2
ENST00000699783.1
B4DTL6
ENST00000373719.8 [O15294-1]
Q9H5T3
A0A8V8TQ64