SHB report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SHB at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006915Biological processapoptotic process
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0001525Biological processangiogenesis
GO_0042100Biological processB cell proliferation
GO_0045624Biological processpositive regulation of T-helper cell differentiation
GO_1900194Biological processnegative regulation of oocyte maturation
GO_0050852Biological processT cell receptor signaling pathway
GO_0071425Biological processhematopoietic stem cell proliferation
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding

IV. Literature review

[source]
Gene nameSHB
Protein nameSH2 domain-containing adapter protein B
Synonyms
DescriptionFUNCTION: Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. .

AccessionsQ15464
ENST00000377707.4 [Q15464-1]