HIPK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0006468Biological processprotein phosphorylation
GO_0009299Biological processmRNA transcription
GO_0043066Biological processnegative regulation of apoptotic process
GO_0043508Biological processnegative regulation of JUN kinase activity
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005524Molecular functionATP binding
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene nameHIPK3
Protein nameHomeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1)
Homeodomain interacting protein kinase 3
SynonymsPKY
FIST3
DYRK6
DescriptionFUNCTION: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). .

AccessionsENST00000379016.7 [Q9H422-2]
ENST00000303296.9 [Q9H422-1]
Q9H422
ENST00000456517.2 [Q9H422-2]
ENST00000531504.5
E9PKD7
ENST00000525975.5 [Q9H422-2]