SH3GLB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042149Biological processcellular response to glucose starvation
GO_2000786Biological processpositive regulation of autophagosome assembly
GO_1903527Biological processpositive regulation of membrane tubulation
GO_0061024Biological processmembrane organization
GO_0090148Biological processmembrane fission
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0048102Biological processautophagic cell death
GO_0010508Biological processpositive regulation of autophagy
GO_0034198Biological processcellular response to amino acid starvation
GO_1903778Biological processprotein localization to vacuolar membrane
GO_0006915Biological processapoptotic process
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0006914Biological processautophagy
GO_0016241Biological processregulation of macroautophagy
GO_0032801Biological processreceptor catabolic process
GO_0031647Biological processregulation of protein stability
GO_0032465Biological processregulation of cytokinesis
GO_0030496Cellular componentmidbody
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0000421Cellular componentautophagosome membrane
GO_0032991Cellular componentprotein-containing complex
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0008289Molecular functionlipid binding
GO_0045296Molecular functioncadherin binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSH3GLB1
Protein nameEndophilin-B1 (SH3 domain-containing GRB2-like protein B1)
Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1)
SynonymsCGI-61
KIAA0491
hCG_25233
DescriptionFUNCTION: May be required for normal outer mitochondrial membrane dynamics . Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion . Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation . Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) . Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation . Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 . Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity). .

AccessionsENST00000705519.1
ENST00000616170.4
A0A994J549
ENST00000370558.8 [Q9Y371-1]
Q9Y371
ENST00000535010.5 [Q9Y371-3]
A0A140VJU5
ENST00000482504.1 [Q9Y371-2]
A0A087WW40