PTPRH report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PTPRH at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PTPRH at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0006470Biological processprotein dephosphorylation
GO_0016324Cellular componentapical plasma membrane
GO_0016607Cellular componentnuclear speck
GO_0031528Cellular componentmicrovillus membrane
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005001Molecular functiontransmembrane receptor protein tyrosine phosphatase activity
GO_0045296Molecular functioncadherin binding
GO_0005515Molecular functionprotein binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPRH
Protein nameReceptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)
SynonymsSAP1
DescriptionFUNCTION: Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity). .

AccessionsENST00000376350.8 [Q9HD43-1]
Q9HD43
ENST00000263434.5 [Q9HD43-3]