NISCH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030036Biological processactin cytoskeleton organization
GO_0016601Biological processRac protein signal transduction
GO_0006915Biological processapoptotic process
GO_0030336Biological processnegative regulation of cell migration
GO_0036158Biological processouter dynein arm assembly
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0005654Cellular componentnucleoplasm
GO_0045171Cellular componentintercellular bridge
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0042802Molecular functionidentical protein binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0005178Molecular functionintegrin binding
GO_0043014Molecular functionalpha-tubulin binding
GO_0005515Molecular functionprotein binding
GO_0045504Molecular functiondynein heavy chain binding

IV. Literature review

[source]
Gene nameNISCH
Protein nameNischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)
Nischarin
SynonymsKIAA0975
IRAS
DescriptionFUNCTION: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures. .

AccessionsENST00000420808.2 [Q9Y2I1-4]
ENST00000488380.5
Q9Y2I1
C9J715
ENST00000479054.5 [Q9Y2I1-1]
ENST00000345716.9 [Q9Y2I1-1]