Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 8 studies | 34% ± 12% | |
| glutamatergic neuron | 8 studies | 40% ± 22% | |
| macrophage | 8 studies | 22% ± 5% | |
| epithelial cell | 5 studies | 28% ± 8% | |
| fibroblast | 5 studies | 22% ± 5% | |
| neuron | 4 studies | 29% ± 6% | |
| myeloid cell | 4 studies | 18% ± 2% | |
| basal cell | 4 studies | 28% ± 13% | |
| GABAergic neuron | 4 studies | 39% ± 20% | |
| oligodendrocyte precursor cell | 4 studies | 30% ± 13% | |
| interneuron | 4 studies | 27% ± 20% | |
| classical monocyte | 3 studies | 26% ± 9% | |
| ciliated cell | 3 studies | 19% ± 3% | |
| type I pneumocyte | 3 studies | 19% ± 4% | |
| astrocyte | 3 studies | 26% ± 4% | |
| enteroendocrine cell | 3 studies | 47% ± 16% | |
| granule cell | 3 studies | 25% ± 7% | |
| oligodendrocyte | 3 studies | 23% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 10 studies | 28% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 27234.18 | 245 / 245 | 100% | 66.02 | 502 / 502 |
| thymus | 100% | 15561.45 | 653 / 653 | 100% | 54.30 | 603 / 605 |
| skin | 100% | 14379.58 | 1809 / 1809 | 100% | 36.76 | 470 / 472 |
| breast | 100% | 14871.96 | 459 / 459 | 99% | 38.35 | 1112 / 1118 |
| esophagus | 100% | 14595.26 | 1445 / 1445 | 99% | 28.57 | 182 / 183 |
| adrenal gland | 100% | 15408.56 | 258 / 258 | 99% | 58.12 | 228 / 230 |
| uterus | 100% | 20764.26 | 170 / 170 | 99% | 34.15 | 455 / 459 |
| intestine | 100% | 14090.38 | 966 / 966 | 99% | 24.97 | 520 / 527 |
| bladder | 100% | 18777.33 | 21 / 21 | 99% | 32.11 | 497 / 504 |
| ovary | 100% | 21243.60 | 180 / 180 | 99% | 36.55 | 424 / 430 |
| pancreas | 99% | 6833.91 | 325 / 328 | 99% | 42.40 | 177 / 178 |
| brain | 98% | 19925.76 | 2593 / 2642 | 100% | 67.26 | 705 / 705 |
| lung | 100% | 13515.97 | 578 / 578 | 98% | 27.36 | 1130 / 1155 |
| kidney | 100% | 11440.65 | 89 / 89 | 98% | 26.06 | 881 / 901 |
| stomach | 100% | 9819.34 | 359 / 359 | 98% | 24.89 | 279 / 286 |
| liver | 96% | 5264.47 | 218 / 226 | 96% | 18.66 | 390 / 406 |
| adipose | 100% | 12710.21 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 31.06 | 29 / 29 |
| spleen | 100% | 13185.45 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 25.66 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 24.84 | 1 / 1 |
| blood vessel | 100% | 12939.31 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 29.91 | 79 / 80 |
| heart | 97% | 7196.08 | 836 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 90% | 5511.68 | 840 / 929 | 0% | 0 | 0 / 0 |
| muscle | 90% | 4519.26 | 721 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0016601 | Biological process | Rac protein signal transduction |
| GO_0006915 | Biological process | apoptotic process |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0036158 | Biological process | outer dynein arm assembly |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0005769 | Cellular component | early endosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0045171 | Cellular component | intercellular bridge |
| GO_0005829 | Cellular component | cytosol |
| GO_0015630 | Cellular component | microtubule cytoskeleton |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0035091 | Molecular function | phosphatidylinositol binding |
| GO_0005178 | Molecular function | integrin binding |
| GO_0043014 | Molecular function | alpha-tubulin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0045504 | Molecular function | dynein heavy chain binding |
| Gene name | NISCH |
| Protein name | Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein) Nischarin |
| Synonyms | KIAA0975 IRAS |
| Description | FUNCTION: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures. . |
| Accessions | ENST00000420808.2 [Q9Y2I1-4] ENST00000488380.5 Q9Y2I1 C9J715 ENST00000479054.5 [Q9Y2I1-1] ENST00000345716.9 [Q9Y2I1-1] |