RFK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0009231Biological processriboflavin biosynthetic process
GO_0009398Biological processFMN biosynthetic process
GO_0072593Biological processreactive oxygen species metabolic process
GO_0033864Biological processpositive regulation of NAD(P)H oxidase activity
GO_0072388Biological processflavin adenine dinucleotide biosynthetic process
GO_0006771Biological processriboflavin metabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0008531Molecular functionriboflavin kinase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameRFK
Protein nameRiboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase)
riboflavin kinase (EC 2.7.1.26)
Synonyms
DescriptionFUNCTION: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. .

AccessionsENST00000490113.1
H7C4G0
Q969G6
ENST00000376736.6