HTT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905337Biological processpositive regulation of aggrephagy
GO_0006890Biological processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO_2000479Biological processregulation of cAMP-dependent protein kinase activity
GO_0042297Biological processvocal learning
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_1904504Biological processpositive regulation of lipophagy
GO_0031648Biological processprotein destabilization
GO_0043666Biological processregulation of phosphoprotein phosphatase activity
GO_0031587Biological processpositive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO_0007030Biological processGolgi organization
GO_0045724Biological processpositive regulation of cilium assembly
GO_1905289Biological processregulation of CAMKK-AMPK signaling cascade
GO_1901526Biological processpositive regulation of mitophagy
GO_0006915Biological processapoptotic process
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_0047496Biological processvesicle transport along microtubule
GO_0099111Biological processmicrotubule-based transport
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005769Cellular componentearly endosome
GO_0032991Cellular componentprotein-containing complex
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0030425Cellular componentdendrite
GO_0005814Cellular componentcentriole
GO_0016234Cellular componentinclusion body
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0099524Cellular componentpostsynaptic cytosol
GO_0005770Cellular componentlate endosome
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0099523Cellular componentpresynaptic cytosol
GO_0030424Cellular componentaxon
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0048487Molecular functionbeta-tubulin binding
GO_0034452Molecular functiondynactin binding
GO_0019900Molecular functionkinase binding
GO_0031072Molecular functionheat shock protein binding
GO_0042802Molecular functionidentical protein binding
GO_0002039Molecular functionp53 binding
GO_0005522Molecular functionprofilin binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0045505Molecular functiondynein intermediate chain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHTT
Protein nameHuntingtin
Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]
Huntingtin isoform A
SynonymsHD
IT15
DescriptionFUNCTION: [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. .

FUNCTION: May play a role in microtubule-mediated transport or vesicle function. .

FUNCTION: May play a role in microtubule-mediated transport or vesicle function. .

FUNCTION: May play a role in microtubule-mediated transport or vesicle function. .

FUNCTION: May play a role in microtubule-mediated transport or vesicle function. .

AccessionsENST00000680239.1
ENST00000680360.1
X5DPA1
A0A7P0TA78
ENST00000650595.1
ENST00000681528.1
A0A7P0TAN5
ENST00000649131.1
ENST00000650588.1
H0YA07
A0A3B3ISR3
P42858
ENST00000680956.1
ENST00000355072.11
A0A7P0TAC5
ENST00000509618.1
A0A3B3IU25
A0A7P0Z417