GDF6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GDF6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GDF6 at tissue level.

III. Associated gene sets

GO_0001656Biological processmetanephros development
GO_0006915Biological processapoptotic process
GO_0030509Biological processBMP signaling pathway
GO_1990009Biological processretinal cell apoptotic process
GO_0060395Biological processSMAD protein signal transduction
GO_0032924Biological processactivin receptor signaling pathway
GO_0032332Biological processpositive regulation of chondrocyte differentiation
GO_0035788Biological processcell migration involved in metanephros development
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045444Biological processfat cell differentiation
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0010631Biological processepithelial cell migration
GO_0005615Cellular componentextracellular space
GO_0008083Molecular functiongrowth factor activity
GO_0042802Molecular functionidentical protein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameGDF6
Protein nameGrowth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)
GDF6 protein
Growth differentiation factor 6
SynonymshCG_15804
BMP13
GDF16
DescriptionFUNCTION: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map . Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG . Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity). .

AccessionsA0A140F382
A0PK22
M1L0V3
A0A140F384
A0PK23
Q6KF10
A0A0S2A5D6
ENST00000287020.7
M1L5L6