TRIM39 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM39 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM39 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0016567Biological processprotein ubiquitination
GO_1902806Biological processregulation of cell cycle G1/S phase transition
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_2000059Biological processnegative regulation of ubiquitin-dependent protein catabolic process
GO_0050821Biological processprotein stabilization
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTRIM39
Protein nameE3 ubiquitin-protein ligase TRIM39 (Tripartite motif containing 39)
E3 ubiquitin-protein ligase TRIM39 (EC 2.3.2.27) (RING finger protein 23) (RING-type E3 ubiquitin transferase TRIM39) (Testis-abundant finger protein) (Tripartite motif-containing protein 39)
SynonymsRNF23
TFP
DescriptionFUNCTION: [Isoform 1]: E3 ubiquitin-protein ligase . May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 . Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation . .; FUNCTION: [Isoform 2]: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 . Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation . Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner . .

AccessionsENST00000428404.5
ENST00000400644.5 [Q9HCM9-2]
ENST00000550282.5 [Q9HCM9-1]
ENST00000450170.1
ENST00000425693.5
ENST00000442914.5
A2AAZ2
ENST00000426384.5
ENST00000450818.5
ENST00000438859.5 [Q9HCM9-2]
ENST00000431871.5
ENST00000424571.5
ENST00000383601.6 [Q9HCM9-2]
ENST00000457343.1
ENST00000426443.1
ENST00000445206.5 [Q9HCM9-1]
ENST00000383603.8 [Q9HCM9-2]
ENST00000396551.9 [Q9HCM9-2]
ENST00000433900.6 [Q9HCM9-2]
ENST00000451715.5 [Q9HCM9-1]
ENST00000418057.5
ENST00000547030.3 [Q9HCM9-1]
ENST00000396547.5 [Q9HCM9-1]
ENST00000396548.5 [Q9HCM9-2]
ENST00000416213.5
ENST00000430414.5
ENST00000434862.5
ENST00000456425.5
ENST00000452705.5 [Q9HCM9-2]
ENST00000419790.6 [Q9HCM9-2]
ENST00000430502.5 [Q9HCM9-2]
ENST00000437257.5
ENST00000429069.5
ENST00000447542.5
A2AAZ4
ENST00000428728.5
ENST00000412150.5
ENST00000424180.5
ENST00000421662.1
ENST00000451132.5 [Q9HCM9-2]
ENST00000424074.5
ENST00000428555.1
Q9HCM9
ENST00000376656.8 [Q9HCM9-1]
ENST00000438168.5
ENST00000434118.5
ENST00000450778.6 [Q9HCM9-2]
ENST00000449396.5
ENST00000458607.5 [Q9HCM9-2]
ENST00000414015.6 [Q9HCM9-2]
ENST00000446397.5 [Q9HCM9-2]
A2AAZ3
ENST00000453856.5
ENST00000549841.3 [Q9HCM9-1]
ENST00000420746.1
ENST00000424575.5 [Q9HCM9-1]
ENST00000441470.5
H0Y735
ENST00000418079.1
ENST00000552520.2 [Q9HCM9-1]
ENST00000426676.5
ENST00000449318.5 [Q9HCM9-2]
ENST00000443109.5 [Q9HCM9-2]
ENST00000440130.5
ENST00000431272.6 [Q9HCM9-2]
ENST00000438089.5
A2AAZ6
ENST00000458516.5
ENST00000450421.5
ENST00000383602.6 [Q9HCM9-1]
ENST00000438076.5 [Q9HCM9-2]
ENST00000440117.5 [Q9HCM9-2]
ENST00000422419.1
A2AAZ5
ENST00000376659.9 [Q9HCM9-2]
ENST00000457154.5
ENST00000440271.5
ENST00000411711.5
ENST00000447077.5
ENST00000548002.1 [Q9HCM9-1]
ENST00000413715.5 [Q9HCM9-1]
ENST00000552337.2 [Q9HCM9-1]
ENST00000426469.5 [Q9HCM9-1]
ENST00000412022.5