CASP12 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CASP12 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CASP12 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0050729Biological processpositive regulation of inflammatory response
GO_0006508Biological processproteolysis
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0072558Cellular componentNLRP1 inflammasome complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0097153Molecular functioncysteine-type endopeptidase activity involved in apoptotic process
GO_0004197Molecular functioncysteine-type endopeptidase activity

IV. Literature review

[source]
Gene nameCASP12
Protein nameInactive caspase-12 (CASP-12)
SynonymsUNQ9415/PRO34398
DescriptionFUNCTION: May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF . May lack protease activity (Probable). .

AccessionsENST00000709452.1 [Q6UXS9-4]
ENST00000709450.1 [Q6UXS9-3]
ENST00000709446.1 [Q6UXS9-1]
ENST00000709451.1 [Q6UXS9-5]
ENST00000709454.1 [Q6UXS9-6]
ENST00000709449.1 [Q6UXS9-2]
ENST00000709456.1 [Q6UXS9-7]
ENST00000709447.1 [Q6UXS9-6]
ENST00000709448.1 [Q6UXS9-1]
ENST00000417998.5 [Q6UXS9-2]
ENST00000458137.5 [Q6UXS9-2]
ENST00000709453.1 [Q6UXS9-8]
ENST00000709455.1 [Q6UXS9-2]
Q6UXS9