TNFSF14 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	7 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	25% ± 5%	Explore
CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNFSF14 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	9303.48	226 / 226	87%	13.52	354 / 406
lung	90%	790.08	521 / 578	69%	2.24	798 / 1155
ovary	61%	688.25	110 / 180	67%	3.22	286 / 430
pancreas	42%	425.84	139 / 328	71%	2.46	127 / 178
breast	64%	403.06	294 / 459	47%	1.16	522 / 1118
esophagus	53%	539.95	765 / 1445	51%	1.65	93 / 183
stomach	41%	285.14	148 / 359	61%	1.72	175 / 286
intestine	59%	500.02	574 / 966	43%	1.06	226 / 527
spleen	99%	590.88	239 / 241	0%	0	0 / 0
peripheral blood	99%	4220.86	921 / 929	0%	0	0 / 0
kidney	33%	159.58	29 / 89	65%	3.57	584 / 901
thymus	50%	422.98	327 / 653	39%	0.84	237 / 605
uterus	40%	255.02	68 / 170	49%	1.51	224 / 459
bladder	48%	589.29	10 / 21	31%	0.78	158 / 504
adipose	75%	2333.73	906 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	69%	3.58	20 / 29
tonsil	0%	0	0 / 0	64%	2.09	29 / 45
adrenal gland	44%	215.48	114 / 258	4%	0.10	9 / 230
prostate	33%	295.97	82 / 245	13%	0.25	64 / 502
skin	10%	43.47	187 / 1809	32%	0.76	150 / 472
heart	39%	264.38	332 / 861	0%	0	0 / 0
blood vessel	29%	228.08	390 / 1335	0%	0	0 / 0
brain	3%	9.29	75 / 2642	20%	0.70	139 / 705
eye	0%	0	0 / 0	6%	0.09	5 / 80
muscle	6%	21.02	50 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0043029	Biological process	T cell homeostasis
GO_1901224	Biological process	positive regulation of non-canonical NF-kappaB signal transduction
GO_0071260	Biological process	cellular response to mechanical stimulus
GO_0042098	Biological process	T cell proliferation
GO_0007165	Biological process	signal transduction
GO_0031295	Biological process	T cell costimulation
GO_0010820	Biological process	positive regulation of T cell chemotaxis
GO_0045663	Biological process	positive regulation of myoblast differentiation
GO_1901741	Biological process	positive regulation of myoblast fusion
GO_0006955	Biological process	immune response
GO_0006915	Biological process	apoptotic process
GO_0010818	Biological process	T cell chemotaxis
GO_0042110	Biological process	T cell activation
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0043027	Molecular function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0005102	Molecular function	signaling receptor binding
GO_0005164	Molecular function	tumor necrosis factor receptor binding
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

Gene name	TNFSF14
Protein name	Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]
Synonyms	LIGHT HVEML UNQ391/PRO726
Description	FUNCTION: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM . Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production . .
Accessions	ENST00000675206.1 [O43557-1] ENST00000245912.7 [O43557-2] ENST00000599359.1 [O43557-1] O43557

TNFSF14 report