RNF216 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0032480Biological processnegative regulation of type I interferon production
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0050691Biological processregulation of defense response to virus by host
GO_0032648Biological processregulation of interferon-beta production
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameRNF216
Protein nameRing finger protein 216
E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B)
SynonymsTRIAD3
UBCE7IP1
ZIN
DescriptionFUNCTION: [Isoform 1]: E3 ubiquitin ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their ubiquitination . Plays a role in the regulation of antiviral responses by promoting the degradation of TRAF3, TLR4 and TLR9 . In turn, down-regulates NF-kappa-B and IRF3 activation as well as beta interferon production. Participates also in the regulation of autophagy by ubiquitinating BECN1 leading to its degradation and autophagy inhibition . Plays a role in ARC-dependent synaptic plasticity by mediating ARC ubiquitination resulting in its rapid proteasomal degradation . Plays aso an essential role in spermatogenesis and male fertility (By similarity). Mechanistically, regulates meiosis by promoting the degradation of PRKACB through the ubiquitin-mediated lysosome pathway (By similarity). Modulates the gonadotropin-releasing hormone signal pathway by affecting the stability of STAU2 that is required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite (By similarity). .; FUNCTION: [Isoform 3]: Inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. .

AccessionsQ9NWF9
F8WDI8
ENST00000389900.8
F8W6D1
ENST00000389902.8 [Q9NWF9-1]
C9JIV3
ENST00000425013.6 [Q9NWF9-2]
ENST00000416985.5
ENST00000411812.1