ARL6IP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	34 studies	39% ± 14%	Explore
natural killer cell	32 studies	30% ± 12%	Explore
endothelial cell	31 studies	34% ± 15%	Explore
B cell	28 studies	27% ± 7%	Explore
fibroblast	28 studies	31% ± 15%	Explore
T cell	26 studies	29% ± 12%	Explore
CD8-positive, alpha-beta T cell	26 studies	32% ± 16%	Explore
CD4-positive, alpha-beta T cell	22 studies	29% ± 15%	Explore
conventional dendritic cell	20 studies	32% ± 11%	Explore
endothelial cell of lymphatic vessel	19 studies	61% ± 17%	Explore
plasmacytoid dendritic cell	19 studies	39% ± 16%	Explore
regulatory T cell	18 studies	30% ± 11%	Explore
classical monocyte	17 studies	28% ± 11%	Explore
epithelial cell	17 studies	44% ± 20%	Explore
pericyte	17 studies	28% ± 8%	Explore
smooth muscle cell	17 studies	25% ± 8%	Explore
mast cell	15 studies	28% ± 8%	Explore
monocyte	15 studies	29% ± 12%	Explore
mature NK T cell	15 studies	28% ± 8%	Explore
non-classical monocyte	15 studies	28% ± 11%	Explore
basal cell	15 studies	34% ± 14%	Explore
connective tissue cell	14 studies	35% ± 12%	Explore
memory B cell	14 studies	24% ± 7%	Explore
astrocyte	13 studies	32% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	29% ± 10%	Explore
ciliated cell	12 studies	31% ± 15%	Explore
gamma-delta T cell	12 studies	28% ± 10%	Explore
naive B cell	11 studies	26% ± 10%	Explore
capillary endothelial cell	11 studies	24% ± 5%	Explore
endothelial cell of vascular tree	11 studies	38% ± 9%	Explore
dendritic cell	10 studies	37% ± 15%	Explore
endothelial cell of artery	10 studies	38% ± 9%	Explore
vein endothelial cell	10 studies	27% ± 6%	Explore
myeloid cell	10 studies	37% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	23% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	31% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	26% ± 8%	Explore
secretory cell	9 studies	36% ± 8%	Explore
plasma cell	8 studies	27% ± 8%	Explore
leukocyte	8 studies	37% ± 10%	Explore
glutamatergic neuron	8 studies	46% ± 18%	Explore
progenitor cell	8 studies	30% ± 4%	Explore
goblet cell	8 studies	29% ± 12%	Explore
microglial cell	8 studies	29% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	34% ± 15%	Explore
oligodendrocyte precursor cell	8 studies	31% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	29% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	40% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	29% ± 9%	Explore
epithelial cell of proximal tubule	7 studies	28% ± 12%	Explore
abnormal cell	7 studies	34% ± 13%	Explore
enterocyte	7 studies	24% ± 6%	Explore
retinal rod cell	7 studies	51% ± 24%	Explore
mucosal invariant T cell	7 studies	31% ± 7%	Explore
precursor B cell	7 studies	34% ± 16%	Explore
oligodendrocyte	7 studies	22% ± 3%	Explore
alveolar macrophage	6 studies	49% ± 17%	Explore
mononuclear phagocyte	6 studies	39% ± 18%	Explore
kidney loop of Henle epithelial cell	6 studies	38% ± 10%	Explore
renal alpha-intercalated cell	6 studies	43% ± 4%	Explore
erythroblast	6 studies	30% ± 22%	Explore
retinal cone cell	6 studies	64% ± 27%	Explore
innate lymphoid cell	6 studies	33% ± 12%	Explore
amacrine cell	6 studies	48% ± 26%	Explore
erythrocyte	6 studies	33% ± 18%	Explore
neuron	6 studies	42% ± 15%	Explore
T follicular helper cell	6 studies	25% ± 7%	Explore
hematopoietic precursor cell	5 studies	28% ± 8%	Explore
plasmablast	5 studies	41% ± 20%	Explore
myofibroblast cell	5 studies	32% ± 10%	Explore
transit amplifying cell	5 studies	43% ± 18%	Explore
OFF-bipolar cell	5 studies	43% ± 24%	Explore
ON-bipolar cell	5 studies	48% ± 22%	Explore
retinal ganglion cell	5 studies	64% ± 33%	Explore
pro-B cell	5 studies	27% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	34% ± 12%	Explore
GABAergic neuron	5 studies	52% ± 14%	Explore
interneuron	5 studies	54% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	35% ± 18%	Explore
pancreatic A cell	4 studies	44% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	44% ± 8%	Explore
exhausted T cell	4 studies	39% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	49% ± 5%	Explore
enteroendocrine cell	4 studies	36% ± 12%	Explore
intestinal crypt stem cell	4 studies	31% ± 6%	Explore
mesothelial cell	4 studies	29% ± 18%	Explore
retinal bipolar neuron	4 studies	49% ± 24%	Explore
GABAergic amacrine cell	4 studies	42% ± 16%	Explore
glycinergic amacrine cell	4 studies	31% ± 14%	Explore
brush cell	4 studies	27% ± 8%	Explore
type I pneumocyte	4 studies	27% ± 9%	Explore
retina horizontal cell	4 studies	43% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	43% ± 15%	Explore
T-helper 17 cell	4 studies	30% ± 12%	Explore
squamous epithelial cell	3 studies	38% ± 26%	Explore
pancreatic D cell	3 studies	41% ± 21%	Explore
type B pancreatic cell	3 studies	56% ± 13%	Explore
glomerular endothelial cell	3 studies	33% ± 8%	Explore
neural crest cell	3 studies	39% ± 14%	Explore
renal principal cell	3 studies	67% ± 9%	Explore
extravillous trophoblast	3 studies	42% ± 7%	Explore
placental villous trophoblast	3 studies	42% ± 7%	Explore
hematopoietic stem cell	3 studies	36% ± 3%	Explore
lymphocyte	3 studies	47% ± 4%	Explore
club cell	3 studies	25% ± 6%	Explore
type II pneumocyte	3 studies	24% ± 10%	Explore
retinal pigment epithelial cell	3 studies	69% ± 24%	Explore
serous secreting cell	3 studies	29% ± 8%	Explore
Mueller cell	3 studies	58% ± 8%	Explore
rod bipolar cell	3 studies	41% ± 13%	Explore
inflammatory macrophage	3 studies	35% ± 10%	Explore
respiratory goblet cell	3 studies	23% ± 11%	Explore
intermediate monocyte	3 studies	32% ± 16%	Explore
CD4-positive helper T cell	3 studies	27% ± 8%	Explore
luminal cell of prostate epithelium	3 studies	30% ± 7%	Explore
monocyte-derived dendritic cell	3 studies	26% ± 8%	Explore
pancreatic ductal cell	3 studies	81% ± 15%	Explore
glial cell	3 studies	36% ± 18%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 10%	Explore
keratinocyte	3 studies	34% ± 14%	Explore
immature B cell	3 studies	25% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	30% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	30% ± 9%	Explore
brain	12 studies	37% ± 15%	Explore
peripheral blood	11 studies	30% ± 7%	Explore
intestine	11 studies	26% ± 10%	Explore
eye	10 studies	45% ± 21%	Explore
kidney	8 studies	32% ± 8%	Explore
liver	7 studies	32% ± 21%	Explore
uterus	6 studies	36% ± 11%	Explore
lymph node	6 studies	24% ± 6%	Explore
pancreas	4 studies	47% ± 17%	Explore
bone marrow	4 studies	23% ± 8%	Explore
prostate	4 studies	34% ± 9%	Explore
breast	4 studies	35% ± 10%	Explore
placenta	3 studies	42% ± 4%	Explore
ovary	3 studies	41% ± 16%	Explore
adrenal gland	3 studies	26% ± 4%	Explore
skin	3 studies	34% ± 6%	Explore
thymus	3 studies	32% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	11831.57	258 / 258	100%	225.51	230 / 230
brain	100%	20135.69	2642 / 2642	100%	300.58	705 / 705
ovary	100%	6440.81	180 / 180	100%	175.32	430 / 430
breast	100%	8416.73	459 / 459	100%	317.56	1117 / 1118
bladder	100%	4980.52	21 / 21	100%	249.92	502 / 504
esophagus	99%	4892.09	1434 / 1445	100%	211.03	183 / 183
thymus	100%	6332.46	651 / 653	99%	153.18	601 / 605
lung	99%	5639.43	572 / 578	100%	189.72	1154 / 1155
intestine	99%	5835.57	961 / 966	99%	216.92	523 / 527
prostate	99%	4309.08	243 / 245	99%	164.38	499 / 502
kidney	99%	5456.22	88 / 89	100%	154.79	897 / 901
uterus	99%	4800.39	168 / 170	100%	235.56	457 / 459
liver	100%	8049.34	226 / 226	98%	142.80	398 / 406
skin	100%	6913.59	1800 / 1809	98%	149.90	463 / 472
stomach	96%	4570.94	345 / 359	99%	204.45	283 / 286
pancreas	89%	2943.57	292 / 328	98%	214.90	175 / 178
lymph node	0%	0	0 / 0	100%	144.65	29 / 29
tonsil	0%	0	0 / 0	100%	187.86	45 / 45
ureter	0%	0	0 / 0	100%	190.81	1 / 1
adipose	100%	8974.58	1203 / 1204	0%	0	0 / 0
spleen	100%	4746.03	240 / 241	0%	0	0 / 0
blood vessel	99%	5240.85	1324 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	93%	76.87	74 / 80
peripheral blood	86%	5398.63	796 / 929	0%	0	0 / 0
heart	54%	1403.63	469 / 861	0%	0	0 / 0
muscle	20%	449.43	164 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043154	Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1990809	Biological process	endoplasmic reticulum tubular network membrane organization
GO_0006915	Biological process	apoptotic process
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0006613	Biological process	cotranslational protein targeting to membrane
GO_1903371	Biological process	regulation of endoplasmic reticulum tubular network organization
GO_0071787	Biological process	endoplasmic reticulum tubular network formation
GO_0002038	Biological process	positive regulation of L-glutamate import across plasma membrane
GO_0005784	Cellular component	Sec61 translocon complex
GO_0071782	Cellular component	endoplasmic reticulum tubular network
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ARL6IP1
Protein name	ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Apoptotic regulator in the membrane of the endoplasmic reticulum) ADP ribosylation factor like GTPase 6 interacting protein 1
Synonyms	KIAA0069 ARL6IP ARMER
Description	FUNCTION: Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules . Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself . May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation . .
Accessions	H3BTX6 ENST00000562819.5 H3BPJ2 ENST00000562234.2 ENST00000304414.12 [Q15041-1] Q15041 ENST00000563861.5 H3BS91 ENST00000546206.6 [Q15041-2]

ARL6IP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review