RASSF5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006915Biological processapoptotic process
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_1900180Biological processregulation of protein localization to nucleus
GO_0050672Biological processnegative regulation of lymphocyte proliferation
GO_0046651Biological processlymphocyte proliferation
GO_0005874Cellular componentmicrotubule
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRASSF5
Protein nameFLJ00186 protein (Ras association domain family member 5)
Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)
Ras association domain family member 5
SynonymsNORE1
FLJ00186
RAPL
DescriptionFUNCTION: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. .

AccessionsENST00000579436.7 [Q8WWW0-1]
Q8WWW0
ENST00000581503.6
ENST00000577571.5 [Q8WWW0-2]
ENST00000636182.1
ENST00000581888.1
A0A075B763
A0A1B0GTG4
Q8TEK8
ENST00000580449.5 [Q8WWW0-3]