SOD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	41 studies	47% ± 19%	Explore
B cell	39 studies	43% ± 11%	Explore
natural killer cell	37 studies	46% ± 12%	Explore
fibroblast	36 studies	57% ± 17%	Explore
CD8-positive, alpha-beta T cell	36 studies	52% ± 19%	Explore
T cell	34 studies	53% ± 17%	Explore
CD4-positive, alpha-beta T cell	32 studies	59% ± 17%	Explore
macrophage	31 studies	42% ± 14%	Explore
pericyte	30 studies	60% ± 18%	Explore
regulatory T cell	26 studies	68% ± 14%	Explore
smooth muscle cell	25 studies	64% ± 15%	Explore
conventional dendritic cell	25 studies	42% ± 16%	Explore
non-classical monocyte	24 studies	49% ± 16%	Explore
epithelial cell	22 studies	58% ± 20%	Explore
mature NK T cell	21 studies	43% ± 14%	Explore
basal cell	21 studies	61% ± 16%	Explore
memory B cell	20 studies	46% ± 10%	Explore
classical monocyte	20 studies	30% ± 11%	Explore
mast cell	19 studies	42% ± 14%	Explore
gamma-delta T cell	19 studies	48% ± 16%	Explore
plasmacytoid dendritic cell	19 studies	34% ± 12%	Explore
dendritic cell	18 studies	38% ± 22%	Explore
monocyte	18 studies	30% ± 10%	Explore
endothelial cell of lymphatic vessel	18 studies	56% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	56% ± 16%	Explore
naive B cell	18 studies	36% ± 8%	Explore
connective tissue cell	18 studies	59% ± 16%	Explore
ciliated cell	17 studies	80% ± 11%	Explore
mucosal invariant T cell	16 studies	43% ± 14%	Explore
plasma cell	16 studies	40% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	42% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	59% ± 11%	Explore
myofibroblast cell	13 studies	64% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	40% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	60% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	55% ± 15%	Explore
secretory cell	12 studies	56% ± 11%	Explore
capillary endothelial cell	12 studies	41% ± 11%	Explore
astrocyte	12 studies	43% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	52% ± 17%	Explore
endothelial cell of artery	11 studies	40% ± 11%	Explore
vein endothelial cell	11 studies	48% ± 12%	Explore
endothelial cell of vascular tree	11 studies	56% ± 11%	Explore
myeloid cell	11 studies	43% ± 14%	Explore
innate lymphoid cell	10 studies	48% ± 17%	Explore
plasmablast	10 studies	50% ± 19%	Explore
progenitor cell	10 studies	63% ± 15%	Explore
abnormal cell	10 studies	60% ± 22%	Explore
oligodendrocyte	10 studies	33% ± 16%	Explore
mesothelial cell	10 studies	58% ± 18%	Explore
glutamatergic neuron	10 studies	34% ± 17%	Explore
platelet	9 studies	27% ± 6%	Explore
goblet cell	9 studies	44% ± 13%	Explore
T follicular helper cell	9 studies	63% ± 15%	Explore
erythrocyte	9 studies	51% ± 25%	Explore
type I pneumocyte	8 studies	49% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	59% ± 18%	Explore
leukocyte	8 studies	51% ± 5%	Explore
enterocyte	8 studies	53% ± 19%	Explore
hematopoietic stem cell	8 studies	53% ± 19%	Explore
type II pneumocyte	7 studies	49% ± 17%	Explore
club cell	7 studies	57% ± 9%	Explore
epithelial cell of proximal tubule	7 studies	71% ± 17%	Explore
neuron	7 studies	60% ± 18%	Explore
erythroblast	7 studies	57% ± 28%	Explore
retinal rod cell	7 studies	45% ± 23%	Explore
microglial cell	7 studies	43% ± 19%	Explore
interneuron	7 studies	40% ± 22%	Explore
ionocyte	6 studies	58% ± 10%	Explore
respiratory goblet cell	6 studies	51% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	74% ± 13%	Explore
kidney loop of Henle epithelial cell	6 studies	73% ± 11%	Explore
renal alpha-intercalated cell	6 studies	74% ± 7%	Explore
transit amplifying cell	6 studies	51% ± 27%	Explore
amacrine cell	6 studies	62% ± 26%	Explore
retinal ganglion cell	6 studies	73% ± 29%	Explore
retinal cone cell	6 studies	54% ± 27%	Explore
precursor B cell	6 studies	44% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	66% ± 13%	Explore
GABAergic neuron	6 studies	33% ± 12%	Explore
oligodendrocyte precursor cell	6 studies	44% ± 20%	Explore
alveolar macrophage	5 studies	46% ± 10%	Explore
CD4-positive helper T cell	5 studies	49% ± 15%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	50% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	43% ± 15%	Explore
hematopoietic precursor cell	5 studies	64% ± 23%	Explore
exhausted T cell	5 studies	66% ± 8%	Explore
mononuclear phagocyte	5 studies	46% ± 17%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	74% ± 5%	Explore
enteroendocrine cell	5 studies	54% ± 21%	Explore
intestinal crypt stem cell	5 studies	55% ± 24%	Explore
pro-B cell	5 studies	45% ± 19%	Explore
brush cell	5 studies	31% ± 19%	Explore
neuroendocrine cell	5 studies	76% ± 13%	Explore
glial cell	5 studies	55% ± 21%	Explore
immature B cell	5 studies	42% ± 16%	Explore
double negative thymocyte	5 studies	64% ± 11%	Explore
hepatocyte	5 studies	60% ± 30%	Explore
granulocyte	5 studies	51% ± 12%	Explore
deuterosomal cell	4 studies	64% ± 13%	Explore
duct epithelial cell	4 studies	67% ± 2%	Explore
pancreatic A cell	4 studies	83% ± 9%	Explore
type B pancreatic cell	4 studies	84% ± 9%	Explore
glomerular endothelial cell	4 studies	55% ± 20%	Explore
podocyte	4 studies	74% ± 10%	Explore
IgG plasma cell	4 studies	22% ± 7%	Explore
OFF-bipolar cell	4 studies	65% ± 27%	Explore
ON-bipolar cell	4 studies	68% ± 26%	Explore
retina horizontal cell	4 studies	76% ± 13%	Explore
retinal pigment epithelial cell	4 studies	54% ± 30%	Explore
adventitial cell	4 studies	57% ± 12%	Explore
mucus secreting cell	4 studies	50% ± 9%	Explore
Mueller cell	4 studies	62% ± 24%	Explore
muscle cell	4 studies	42% ± 24%	Explore
germinal center B cell	4 studies	47% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	71% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	63% ± 31%	Explore
group 3 innate lymphoid cell	4 studies	63% ± 13%	Explore
T-helper 17 cell	4 studies	60% ± 22%	Explore
T-helper 1 cell	4 studies	67% ± 14%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	59% ± 23%	Explore
precursor cell	3 studies	73% ± 9%	Explore
pancreatic D cell	3 studies	79% ± 14%	Explore
kidney connecting tubule epithelial cell	3 studies	78% ± 13%	Explore
neural crest cell	3 studies	63% ± 16%	Explore
retinal bipolar neuron	3 studies	71% ± 26%	Explore
GABAergic amacrine cell	3 studies	64% ± 19%	Explore
glycinergic amacrine cell	3 studies	54% ± 21%	Explore
renal principal cell	3 studies	75% ± 10%	Explore
thymocyte	3 studies	61% ± 26%	Explore
extravillous trophoblast	3 studies	64% ± 14%	Explore
placental villous trophoblast	3 studies	87% ± 13%	Explore
lymphocyte	3 studies	58% ± 9%	Explore
megakaryocyte	3 studies	36% ± 9%	Explore
Schwann cell	3 studies	55% ± 28%	Explore
serous secreting cell	3 studies	44% ± 6%	Explore
intraepithelial lymphocyte	3 studies	52% ± 14%	Explore
rod bipolar cell	3 studies	69% ± 21%	Explore
acinar cell	3 studies	45% ± 30%	Explore
cardiac muscle cell	3 studies	26% ± 8%	Explore
endothelial cell of sinusoid	3 studies	29% ± 7%	Explore
neutrophil	3 studies	19% ± 2%	Explore
intermediate monocyte	3 studies	56% ± 18%	Explore
IgA plasma cell	3 studies	20% ± 6%	Explore
myoepithelial cell	3 studies	59% ± 6%	Explore
inflammatory macrophage	3 studies	28% ± 3%	Explore
luminal cell of prostate epithelium	3 studies	63% ± 8%	Explore
pancreatic ductal cell	3 studies	83% ± 5%	Explore
keratinocyte	3 studies	54% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	67% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	52% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	45% ± 13%	Explore
lung	18 studies	53% ± 15%	Explore
brain	14 studies	36% ± 13%	Explore
intestine	13 studies	45% ± 20%	Explore
eye	10 studies	53% ± 24%	Explore
kidney	9 studies	60% ± 15%	Explore
liver	8 studies	48% ± 23%	Explore
bone marrow	6 studies	37% ± 13%	Explore
lymph node	6 studies	56% ± 14%	Explore
pancreas	5 studies	66% ± 25%	Explore
uterus	5 studies	60% ± 18%	Explore
placenta	4 studies	54% ± 24%	Explore
prostate	4 studies	61% ± 11%	Explore
breast	4 studies	60% ± 4%	Explore
adrenal gland	3 studies	55% ± 8%	Explore
esophagus	3 studies	61% ± 22%	Explore
skin	3 studies	44% ± 17%	Explore
thymus	3 studies	68% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	22857.92	258 / 258	100%	514.16	230 / 230
brain	100%	16211.56	2642 / 2642	100%	414.44	705 / 705
esophagus	100%	8645.09	1445 / 1445	100%	205.78	183 / 183
kidney	100%	15508.92	89 / 89	100%	307.65	901 / 901
liver	100%	26174.67	226 / 226	100%	767.39	406 / 406
ovary	100%	11480.64	180 / 180	100%	256.80	430 / 430
stomach	100%	6712.71	359 / 359	100%	266.96	286 / 286
uterus	100%	7683.25	170 / 170	100%	353.36	459 / 459
skin	100%	7044.85	1807 / 1809	100%	317.95	472 / 472
thymus	100%	8590.53	652 / 653	100%	352.67	604 / 605
bladder	100%	9409.67	21 / 21	100%	343.74	502 / 504
breast	100%	9491.89	459 / 459	99%	399.14	1112 / 1118
intestine	100%	9606.12	966 / 966	99%	334.07	524 / 527
lung	99%	6346.75	574 / 578	100%	278.89	1154 / 1155
prostate	100%	8557.01	244 / 245	99%	382.82	499 / 502
pancreas	77%	2316.52	251 / 328	99%	285.23	177 / 178
adipose	100%	10128.39	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	335.37	80 / 80
lymph node	0%	0	0 / 0	100%	494.88	29 / 29
spleen	100%	5938.12	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	296.02	45 / 45
ureter	0%	0	0 / 0	100%	197.63	1 / 1
blood vessel	100%	11351.92	1334 / 1335	0%	0	0 / 0
muscle	100%	9710.66	802 / 803	0%	0	0 / 0
heart	97%	11147.32	831 / 861	0%	0	0 / 0
peripheral blood	62%	3587.92	576 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0046620	Biological process	regulation of organ growth
GO_0042542	Biological process	response to hydrogen peroxide
GO_0051093	Biological process	negative regulation of developmental process
GO_0046716	Biological process	muscle cell cellular homeostasis
GO_0001541	Biological process	ovarian follicle development
GO_0060088	Biological process	auditory receptor cell stereocilium organization
GO_0060087	Biological process	relaxation of vascular associated smooth muscle
GO_0043085	Biological process	positive regulation of catalytic activity
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0019430	Biological process	removal of superoxide radicals
GO_0033081	Biological process	regulation of T cell differentiation in thymus
GO_0007626	Biological process	locomotory behavior
GO_0035234	Biological process	ectopic germ cell programmed cell death
GO_0045859	Biological process	regulation of protein kinase activity
GO_0009408	Biological process	response to heat
GO_0008089	Biological process	anterograde axonal transport
GO_0008217	Biological process	regulation of blood pressure
GO_0072593	Biological process	reactive oxygen species metabolic process
GO_0043087	Biological process	regulation of GTPase activity
GO_0006879	Biological process	intracellular iron ion homeostasis
GO_0019228	Biological process	neuronal action potential
GO_0050665	Biological process	hydrogen peroxide biosynthetic process
GO_0032930	Biological process	positive regulation of superoxide anion generation
GO_0010467	Biological process	gene expression
GO_0001819	Biological process	positive regulation of cytokine production
GO_0006749	Biological process	glutathione metabolic process
GO_0007566	Biological process	embryo implantation
GO_0007605	Biological process	sensory perception of sound
GO_0001895	Biological process	retina homeostasis
GO_0008090	Biological process	retrograde axonal transport
GO_0042554	Biological process	superoxide anion generation
GO_0045541	Biological process	negative regulation of cholesterol biosynthetic process
GO_0099610	Biological process	action potential initiation
GO_0045471	Biological process	response to ethanol
GO_0048538	Biological process	thymus development
GO_1902177	Biological process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0006801	Biological process	superoxide metabolic process
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0050766	Biological process	positive regulation of phagocytosis
GO_0002262	Biological process	myeloid cell homeostasis
GO_0007283	Biological process	spermatogenesis
GO_0060052	Biological process	neurofilament cytoskeleton organization
GO_0008340	Biological process	determination of adult lifespan
GO_0000303	Biological process	response to superoxide
GO_0048678	Biological process	response to axon injury
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0040014	Biological process	regulation of multicellular organism growth
GO_0001890	Biological process	placenta development
GO_0051881	Biological process	regulation of mitochondrial membrane potential
GO_0032287	Biological process	peripheral nervous system myelin maintenance
GO_0060047	Biological process	heart contraction
GO_2000242	Biological process	negative regulation of reproductive process
GO_0006915	Biological process	apoptotic process
GO_0019226	Biological process	transmission of nerve impulse
GO_0043025	Cellular component	neuronal cell body
GO_0032839	Cellular component	dendrite cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005777	Cellular component	peroxisome
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0005739	Cellular component	mitochondrion
GO_0005758	Cellular component	mitochondrial intermembrane space
GO_0032991	Cellular component	protein-containing complex
GO_0005737	Cellular component	cytoplasm
GO_1904115	Cellular component	axon cytoplasm
GO_0005829	Cellular component	cytosol
GO_0005759	Cellular component	mitochondrial matrix
GO_0042802	Molecular function	identical protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0004784	Molecular function	superoxide dismutase activity
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0005507	Molecular function	copper ion binding
GO_0005515	Molecular function	protein binding
GO_0031267	Molecular function	small GTPase binding
GO_0030346	Molecular function	protein phosphatase 2B binding

IV. Literature review

[source]

Gene name	SOD1
Protein name	Superoxide dismutase 1 Truncated superoxide dismutase (EC 1.15.1.1) Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) Alternative protein SOD1 Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) Superoxide dismutase (EC 1.15.1.1)
Synonyms
Description	FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. . FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. .
Accessions	X5CQ60 X5D3F9 X5D3G4 P00441 X5CHU1 ENST00000270142.11 A1YYW4 ENST00000389995.4 H7BYH4 X5CN18 L8E9E6 X5D5A9

SOD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review