CITED1 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CITED1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	94%	196.49	616 / 653	71%	7.76	428 / 605
brain	95%	350.90	2506 / 2642	27%	0.80	188 / 705
eye	0%	0	0 / 0	100%	31.27	80 / 80
prostate	91%	313.51	222 / 245	9%	0.19	45 / 502
breast	82%	213.61	378 / 459	4%	0.09	44 / 1118
uterus	51%	67.02	87 / 170	2%	0.05	11 / 459
kidney	49%	103.69	44 / 89	0%	0.00	2 / 901
adrenal gland	43%	105.80	110 / 258	6%	0.28	14 / 230
ovary	44%	31.08	79 / 180	2%	0.04	7 / 430
esophagus	44%	29.43	629 / 1445	1%	0.01	1 / 183
adipose	43%	38.06	517 / 1204	0%	0	0 / 0
skin	4%	3.19	67 / 1809	38%	1.17	178 / 472
intestine	30%	14.08	287 / 966	4%	0.06	21 / 527
pancreas	20%	8.20	66 / 328	1%	0.02	2 / 178
stomach	16%	11.54	56 / 359	2%	0.05	7 / 286
lung	13%	7.00	74 / 578	1%	0.01	7 / 1155
blood vessel	13%	6.75	171 / 1335	0%	0	0 / 0
bladder	5%	1.48	1 / 21	2%	0.04	8 / 504
heart	5%	3.20	39 / 861	0%	0	0 / 0
spleen	2%	1.02	6 / 241	0%	0	0 / 0
liver	1%	1.75	2 / 226	0%	0.00	1 / 406
muscle	1%	0.79	7 / 803	0%	0	0 / 0
peripheral blood	0%	0.06	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030511	Biological process	positive regulation of transforming growth factor beta receptor signaling pathway
GO_0071107	Biological process	response to parathyroid hormone
GO_0060231	Biological process	mesenchymal to epithelial transition
GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_0043627	Biological process	response to estrogen
GO_0034097	Biological process	response to cytokine
GO_0042438	Biological process	melanin biosynthetic process
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0001656	Biological process	metanephros development
GO_0010628	Biological process	positive regulation of gene expression
GO_0032868	Biological process	response to insulin
GO_0001570	Biological process	vasculogenesis
GO_0071104	Biological process	response to interleukin-9
GO_0071559	Biological process	response to transforming growth factor beta
GO_0070555	Biological process	response to interleukin-1
GO_1902462	Biological process	positive regulation of mesenchymal stem cell proliferation
GO_0034341	Biological process	response to type II interferon
GO_0001890	Biological process	placenta development
GO_0071105	Biological process	response to interleukin-11
GO_0030178	Biological process	negative regulation of Wnt signaling pathway
GO_0070741	Biological process	response to interleukin-6
GO_0060395	Biological process	SMAD protein signal transduction
GO_0051591	Biological process	response to cAMP
GO_0042981	Biological process	regulation of apoptotic process
GO_0030318	Biological process	melanocyte differentiation
GO_0060711	Biological process	labyrinthine layer development
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0070669	Biological process	response to interleukin-2
GO_0043473	Biological process	pigmentation
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0070670	Biological process	response to interleukin-4
GO_0006913	Biological process	nucleocytoplasmic transport
GO_0007420	Biological process	brain development
GO_0006915	Biological process	apoptotic process
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0032496	Biological process	response to lipopolysaccharide
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0050693	Molecular function	LBD domain binding
GO_0003682	Molecular function	chromatin binding
GO_0070410	Molecular function	co-SMAD binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CITED1
Protein name	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1)
Synonyms	MSG1
Description	FUNCTION: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. .
Accessions	ENST00000445983.5 [Q99966-1] C9J300 ENST00000651998.1 [Q99966-1] ENST00000429794.1 ENST00000246139.9 [Q99966-1] Q99966 ENST00000373619.7 [Q99966-1] H7C2S6 ENST00000453707.6 [Q99966-2] ENST00000450875.5 ENST00000427412.5 C9J7P8 ENST00000417400.1 ENST00000454225.1 ENST00000431381.5 [Q99966-2] C9JRD8 C9J1P6

CITED1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review