FKBP8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	31 studies	38% ± 14%	Explore
natural killer cell	30 studies	33% ± 11%	Explore
CD8-positive, alpha-beta T cell	30 studies	34% ± 13%	Explore
CD4-positive, alpha-beta T cell	29 studies	34% ± 12%	Explore
B cell	28 studies	30% ± 11%	Explore
T cell	27 studies	32% ± 12%	Explore
endothelial cell	27 studies	32% ± 14%	Explore
macrophage	26 studies	30% ± 10%	Explore
pericyte	25 studies	37% ± 13%	Explore
classical monocyte	23 studies	34% ± 16%	Explore
smooth muscle cell	22 studies	36% ± 12%	Explore
regulatory T cell	21 studies	38% ± 12%	Explore
conventional dendritic cell	20 studies	36% ± 16%	Explore
non-classical monocyte	19 studies	41% ± 17%	Explore
monocyte	17 studies	32% ± 9%	Explore
mature NK T cell	17 studies	32% ± 10%	Explore
basal cell	17 studies	32% ± 17%	Explore
endothelial cell of lymphatic vessel	16 studies	33% ± 13%	Explore
memory B cell	15 studies	28% ± 6%	Explore
connective tissue cell	15 studies	38% ± 14%	Explore
epithelial cell	15 studies	40% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	36% ± 13%	Explore
gamma-delta T cell	14 studies	37% ± 14%	Explore
dendritic cell	13 studies	41% ± 23%	Explore
myofibroblast cell	13 studies	39% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	36% ± 15%	Explore
ciliated cell	12 studies	42% ± 14%	Explore
naive B cell	12 studies	26% ± 6%	Explore
mast cell	11 studies	24% ± 4%	Explore
erythrocyte	11 studies	69% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	35% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	30% ± 10%	Explore
endothelial cell of artery	11 studies	31% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	34% ± 12%	Explore
plasma cell	10 studies	39% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	37% ± 14%	Explore
capillary endothelial cell	10 studies	27% ± 12%	Explore
myeloid cell	10 studies	30% ± 13%	Explore
plasmablast	9 studies	40% ± 24%	Explore
platelet	9 studies	36% ± 11%	Explore
plasmacytoid dendritic cell	9 studies	28% ± 11%	Explore
abnormal cell	9 studies	33% ± 14%	Explore
oligodendrocyte	9 studies	23% ± 8%	Explore
vein endothelial cell	9 studies	29% ± 14%	Explore
mucosal invariant T cell	9 studies	32% ± 9%	Explore
type I pneumocyte	8 studies	33% ± 19%	Explore
secretory cell	8 studies	28% ± 10%	Explore
T follicular helper cell	8 studies	36% ± 6%	Explore
endothelial cell of vascular tree	8 studies	25% ± 6%	Explore
club cell	7 studies	27% ± 10%	Explore
progenitor cell	7 studies	37% ± 16%	Explore
neuron	7 studies	50% ± 20%	Explore
goblet cell	7 studies	24% ± 11%	Explore
glutamatergic neuron	7 studies	39% ± 19%	Explore
innate lymphoid cell	7 studies	27% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	39% ± 13%	Explore
epithelial cell of proximal tubule	6 studies	28% ± 9%	Explore
astrocyte	6 studies	29% ± 13%	Explore
enterocyte	6 studies	26% ± 8%	Explore
type II pneumocyte	6 studies	35% ± 19%	Explore
hematopoietic precursor cell	5 studies	46% ± 24%	Explore
exhausted T cell	5 studies	45% ± 13%	Explore
neutrophil	5 studies	21% ± 3%	Explore
respiratory goblet cell	5 studies	23% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	38% ± 15%	Explore
leukocyte	5 studies	30% ± 9%	Explore
mononuclear phagocyte	5 studies	34% ± 19%	Explore
kidney loop of Henle epithelial cell	5 studies	28% ± 4%	Explore
erythroblast	5 studies	48% ± 30%	Explore
mesothelial cell	5 studies	45% ± 18%	Explore
GABAergic neuron	5 studies	34% ± 16%	Explore
precursor B cell	5 studies	30% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	45% ± 18%	Explore
CD4-positive helper T cell	4 studies	24% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	26% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	41% ± 7%	Explore
enteroendocrine cell	4 studies	44% ± 18%	Explore
intestinal crypt stem cell	4 studies	22% ± 4%	Explore
retinal ganglion cell	4 studies	83% ± 20%	Explore
retinal cone cell	4 studies	39% ± 19%	Explore
hematopoietic stem cell	4 studies	40% ± 11%	Explore
immature B cell	4 studies	40% ± 16%	Explore
amacrine cell	4 studies	50% ± 18%	Explore
retina horizontal cell	4 studies	41% ± 19%	Explore
adventitial cell	4 studies	26% ± 9%	Explore
alveolar macrophage	4 studies	21% ± 4%	Explore
intermediate monocyte	4 studies	43% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	29% ± 9%	Explore
granulocyte	4 studies	34% ± 9%	Explore
T-helper 17 cell	4 studies	37% ± 11%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	40% ± 17%	Explore
duct epithelial cell	3 studies	22% ± 6%	Explore
ionocyte	3 studies	29% ± 6%	Explore
squamous epithelial cell	3 studies	43% ± 21%	Explore
pancreatic A cell	3 studies	43% ± 15%	Explore
glomerular endothelial cell	3 studies	24% ± 4%	Explore
renal alpha-intercalated cell	3 studies	36% ± 12%	Explore
neural crest cell	3 studies	30% ± 4%	Explore
IgG plasma cell	3 studies	23% ± 4%	Explore
ON-bipolar cell	3 studies	49% ± 35%	Explore
extravillous trophoblast	3 studies	37% ± 5%	Explore
placental villous trophoblast	3 studies	36% ± 18%	Explore
lymphocyte	3 studies	35% ± 11%	Explore
megakaryocyte	3 studies	47% ± 11%	Explore
pro-B cell	3 studies	39% ± 10%	Explore
retinal rod cell	3 studies	28% ± 7%	Explore
microglial cell	3 studies	29% ± 12%	Explore
serous secreting cell	3 studies	27% ± 9%	Explore
intraepithelial lymphocyte	3 studies	36% ± 9%	Explore
Mueller cell	3 studies	33% ± 5%	Explore
germinal center B cell	3 studies	29% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	50% ± 7%	Explore
myoepithelial cell	3 studies	35% ± 6%	Explore
oligodendrocyte precursor cell	3 studies	30% ± 2%	Explore
brush cell	3 studies	27% ± 8%	Explore
glial cell	3 studies	38% ± 18%	Explore
group 3 innate lymphoid cell	3 studies	48% ± 12%	Explore
T-helper 1 cell	3 studies	48% ± 10%	Explore
progenitor cell of mammary luminal epithelium	3 studies	27% ± 3%	Explore
luminal cell of prostate epithelium	3 studies	24% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	33% ± 14%	Explore
peripheral blood	15 studies	36% ± 14%	Explore
brain	11 studies	28% ± 12%	Explore
intestine	10 studies	28% ± 13%	Explore
kidney	7 studies	32% ± 6%	Explore
eye	6 studies	34% ± 10%	Explore
liver	6 studies	33% ± 26%	Explore
lymph node	5 studies	34% ± 8%	Explore
placenta	4 studies	32% ± 16%	Explore
breast	4 studies	28% ± 6%	Explore
pancreas	3 studies	35% ± 21%	Explore
bone marrow	3 studies	27% ± 7%	Explore
uterus	3 studies	40% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	11828.82	258 / 258	100%	475.20	230 / 230
esophagus	100%	18768.37	1445 / 1445	100%	218.34	183 / 183
ovary	100%	19026.62	180 / 180	100%	410.41	430 / 430
uterus	100%	16732.32	170 / 170	100%	339.66	459 / 459
brain	100%	30817.08	2640 / 2642	100%	487.17	705 / 705
thymus	100%	16828.96	651 / 653	100%	455.97	605 / 605
liver	100%	9325.54	225 / 226	100%	265.83	406 / 406
kidney	100%	13307.46	89 / 89	99%	291.06	896 / 901
skin	100%	13841.21	1808 / 1809	99%	360.75	469 / 472
prostate	100%	19908.75	245 / 245	99%	436.18	498 / 502
intestine	100%	17599.49	966 / 966	99%	256.03	521 / 527
stomach	99%	11799.35	357 / 359	99%	227.63	283 / 286
breast	100%	15804.25	459 / 459	98%	249.96	1094 / 1118
bladder	100%	17531.57	21 / 21	98%	301.90	493 / 504
lung	99%	14665.52	575 / 578	98%	257.52	1133 / 1155
pancreas	95%	6511.08	313 / 328	99%	301.65	177 / 178
eye	0%	0	0 / 0	100%	461.26	80 / 80
lymph node	0%	0	0 / 0	100%	431.62	29 / 29
peripheral blood	100%	130050.94	929 / 929	0%	0	0 / 0
spleen	100%	14625.10	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	295.31	45 / 45
ureter	0%	0	0 / 0	100%	287.31	1 / 1
blood vessel	100%	20953.34	1334 / 1335	0%	0	0 / 0
adipose	100%	15371.72	1203 / 1204	0%	0	0 / 0
heart	98%	11693.20	843 / 861	0%	0	0 / 0
muscle	97%	8796.97	781 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1901524	Biological process	regulation of mitophagy
GO_0010468	Biological process	regulation of gene expression
GO_0007224	Biological process	smoothened signaling pathway
GO_0070585	Biological process	protein localization to mitochondrion
GO_0048665	Biological process	neuron fate specification
GO_0035264	Biological process	multicellular organism growth
GO_0021904	Biological process	dorsal/ventral neural tube patterning
GO_0030509	Biological process	BMP signaling pathway
GO_0006457	Biological process	protein folding
GO_0001933	Biological process	negative regulation of protein phosphorylation
GO_0035556	Biological process	intracellular signal transduction
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0030513	Biological process	positive regulation of BMP signaling pathway
GO_0006915	Biological process	apoptotic process
GO_0043010	Biological process	camera-type eye development
GO_0012505	Cellular component	endomembrane system
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005739	Cellular component	mitochondrion
GO_0005740	Cellular component	mitochondrial envelope
GO_0031966	Cellular component	mitochondrial membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0003755	Molecular function	peptidyl-prolyl cis-trans isomerase activity
GO_0044183	Molecular function	protein folding chaperone
GO_0042802	Molecular function	identical protein binding
GO_0046872	Molecular function	metal ion binding
GO_0005516	Molecular function	calmodulin binding
GO_0097718	Molecular function	disordered domain specific binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	FKBP8
Protein name	Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) peptidylprolyl isomerase (EC 5.2.1.8) FKBP prolyl isomerase 8
Synonyms	FKBP38
Description	FUNCTION: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) . .
Accessions	U3KQI1 M0R1S6 Q14318 ENST00000609656.1 ENST00000606531.2 V9GZ05 ENST00000594844.5 ENST00000596558.6 [Q14318-1] ENST00000599540.6 ENST00000596015.1 M0R1Q0 ENST00000608443.6 [Q14318-2] ENST00000222308.8 [Q14318-1] U3KQ64 ENST00000597611.7 ENST00000597547.1 ENST00000601844.5 M0R304 ENST00000597960.7 [Q14318-2] ENST00000544835.7 M0R2K9 M0R2Q6 A0A0A0MTJ1

FKBP8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review