PDCL3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
regulatory T cell	13 studies	18% ± 2%	Explore
CD4-positive, alpha-beta T cell	11 studies	19% ± 3%	Explore
natural killer cell	10 studies	18% ± 3%	Explore
T cell	7 studies	22% ± 3%	Explore
CD8-positive, alpha-beta T cell	6 studies	18% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	18% ± 1%	Explore
non-classical monocyte	5 studies	28% ± 10%	Explore
epithelial cell	5 studies	34% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	24% ± 8%	Explore
gamma-delta T cell	5 studies	25% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	17% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	18% ± 1%	Explore
conventional dendritic cell	4 studies	39% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 5%	Explore
smooth muscle cell	4 studies	17% ± 1%	Explore
endothelial cell	4 studies	22% ± 7%	Explore
mast cell	4 studies	23% ± 8%	Explore
plasmablast	3 studies	43% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	18% ± 1%	Explore
hematopoietic precursor cell	3 studies	20% ± 3%	Explore
mature NK T cell	3 studies	22% ± 8%	Explore
ciliated cell	3 studies	30% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	24% ± 5%	Explore
macrophage	3 studies	26% ± 5%	Explore
dendritic cell	3 studies	44% ± 8%	Explore
mucosal invariant T cell	3 studies	18% ± 1%	Explore
T-helper 17 cell	3 studies	20% ± 4%	Explore
plasmacytoid dendritic cell	3 studies	21% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	4 studies	23% ± 8%	Explore
peripheral blood	3 studies	21% ± 3%	Explore
liver	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1392.90	1445 / 1445	100%	38.80	183 / 183
intestine	100%	1140.65	966 / 966	100%	48.45	527 / 527
ovary	100%	749.85	180 / 180	100%	46.98	430 / 430
prostate	100%	989.49	245 / 245	100%	65.46	501 / 502
uterus	100%	1066.59	170 / 170	100%	63.73	458 / 459
thymus	100%	646.35	652 / 653	100%	42.34	604 / 605
stomach	100%	685.32	359 / 359	100%	44.36	285 / 286
breast	100%	819.13	459 / 459	100%	66.44	1114 / 1118
skin	100%	1133.20	1809 / 1809	100%	44.85	470 / 472
lung	100%	902.97	577 / 578	100%	53.96	1152 / 1155
bladder	100%	1855.24	21 / 21	99%	58.29	501 / 504
brain	99%	694.27	2625 / 2642	100%	37.22	705 / 705
kidney	100%	843.08	89 / 89	99%	37.92	893 / 901
adrenal gland	100%	924.86	258 / 258	98%	30.39	226 / 230
pancreas	94%	339.85	308 / 328	99%	38.38	177 / 178
liver	87%	305.25	196 / 226	99%	25.38	400 / 406
adipose	100%	832.16	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1314.62	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	41.92	80 / 80
lymph node	0%	0	0 / 0	100%	54.96	29 / 29
spleen	100%	711.12	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	58.96	45 / 45
ureter	0%	0	0 / 0	100%	50.07	1 / 1
muscle	100%	1483.03	802 / 803	0%	0	0 / 0
heart	97%	773.09	832 / 861	0%	0	0 / 0
peripheral blood	83%	554.03	767 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001525	Biological process	angiogenesis
GO_2000059	Biological process	negative regulation of ubiquitin-dependent protein catabolic process
GO_0061077	Biological process	chaperone-mediated protein folding
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0010628	Biological process	positive regulation of gene expression
GO_0050730	Biological process	regulation of peptidyl-tyrosine phosphorylation
GO_0006457	Biological process	protein folding
GO_0030036	Biological process	actin cytoskeleton organization
GO_0001938	Biological process	positive regulation of endothelial cell proliferation
GO_0050821	Biological process	protein stabilization
GO_1903645	Biological process	negative regulation of chaperone-mediated protein folding
GO_0006915	Biological process	apoptotic process
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0097356	Cellular component	perinucleolar compartment
GO_0044183	Molecular function	protein folding chaperone
GO_0043184	Molecular function	vascular endothelial growth factor receptor 2 binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PDCL3
Protein name	Phosducin-like protein 3 Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1)
Synonyms	VIAF1 PhLP2A
Description	FUNCTION: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation . Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding . Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis . .
Accessions	C9JST4 H7BZP2 Q9H2J4 ENST00000264254.11 ENST00000450127.1 ENST00000416255.5

PDCL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review