SRGN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	55 studies	75% ± 23%	Explore
natural killer cell	51 studies	84% ± 20%	Explore
endothelial cell	46 studies	52% ± 24%	Explore
T cell	43 studies	64% ± 25%	Explore
CD8-positive, alpha-beta T cell	41 studies	73% ± 19%	Explore
CD4-positive, alpha-beta T cell	36 studies	67% ± 20%	Explore
mast cell	34 studies	78% ± 23%	Explore
B cell	33 studies	42% ± 20%	Explore
dendritic cell	33 studies	79% ± 22%	Explore
conventional dendritic cell	31 studies	88% ± 14%	Explore
monocyte	29 studies	81% ± 21%	Explore
classical monocyte	29 studies	92% ± 11%	Explore
non-classical monocyte	28 studies	90% ± 15%	Explore
plasmacytoid dendritic cell	28 studies	86% ± 10%	Explore
regulatory T cell	28 studies	79% ± 18%	Explore
plasma cell	26 studies	69% ± 23%	Explore
mature NK T cell	26 studies	79% ± 17%	Explore
gamma-delta T cell	21 studies	79% ± 15%	Explore
neutrophil	20 studies	88% ± 14%	Explore
microglial cell	19 studies	50% ± 25%	Explore
endothelial cell of artery	18 studies	69% ± 23%	Explore
myeloid cell	18 studies	74% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	82% ± 18%	Explore
mucosal invariant T cell	17 studies	74% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	47% ± 23%	Explore
memory B cell	17 studies	37% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	84% ± 16%	Explore
naive B cell	16 studies	25% ± 11%	Explore
capillary endothelial cell	16 studies	49% ± 16%	Explore
pericyte	15 studies	43% ± 19%	Explore
fibroblast	14 studies	31% ± 12%	Explore
endothelial cell of vascular tree	14 studies	58% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	68% ± 25%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	77% ± 21%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	54% ± 26%	Explore
innate lymphoid cell	12 studies	82% ± 20%	Explore
plasmablast	12 studies	71% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	73% ± 17%	Explore
vein endothelial cell	12 studies	55% ± 18%	Explore
platelet	11 studies	71% ± 21%	Explore
leukocyte	11 studies	73% ± 24%	Explore
T follicular helper cell	10 studies	87% ± 12%	Explore
smooth muscle cell	9 studies	40% ± 19%	Explore
IgG plasma cell	9 studies	56% ± 20%	Explore
alveolar macrophage	8 studies	69% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	81% ± 23%	Explore
mononuclear phagocyte	8 studies	83% ± 14%	Explore
IgA plasma cell	8 studies	63% ± 22%	Explore
hematopoietic stem cell	8 studies	67% ± 23%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	81% ± 18%	Explore
CD4-positive helper T cell	6 studies	78% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	67% ± 20%	Explore
hematopoietic precursor cell	6 studies	64% ± 21%	Explore
erythrocyte	6 studies	41% ± 15%	Explore
megakaryocyte	6 studies	75% ± 28%	Explore
intermediate monocyte	6 studies	88% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	74% ± 16%	Explore
granulocyte	6 studies	84% ± 18%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	70% ± 22%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	57% ± 15%	Explore
exhausted T cell	5 studies	84% ± 10%	Explore
lymphocyte	5 studies	48% ± 30%	Explore
T-helper 17 cell	5 studies	87% ± 10%	Explore
group 3 innate lymphoid cell	5 studies	91% ± 4%	Explore
myofibroblast cell	5 studies	36% ± 20%	Explore
inflammatory macrophage	5 studies	79% ± 12%	Explore
double negative thymocyte	5 studies	75% ± 17%	Explore
endothelial cell of lymphatic vessel	4 studies	25% ± 7%	Explore
monocyte-derived dendritic cell	4 studies	98% ± 1%	Explore
glomerular endothelial cell	4 studies	54% ± 15%	Explore
erythroblast	4 studies	36% ± 20%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	66% ± 28%	Explore
T-helper 1 cell	4 studies	87% ± 9%	Explore
Langerhans cell	3 studies	73% ± 1%	Explore
thymocyte	3 studies	48% ± 31%	Explore
common myeloid progenitor	3 studies	73% ± 26%	Explore
tissue-resident macrophage	3 studies	85% ± 16%	Explore
intraepithelial lymphocyte	3 studies	80% ± 7%	Explore
germinal center B cell	3 studies	23% ± 3%	Explore
IgM plasma cell	3 studies	57% ± 7%	Explore
connective tissue cell	3 studies	42% ± 32%	Explore
granulocyte monocyte progenitor cell	3 studies	81% ± 13%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	59% ± 7%	Explore
double-positive, alpha-beta thymocyte	3 studies	70% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	22 studies	65% ± 17%	Explore
lung	15 studies	46% ± 21%	Explore
kidney	7 studies	42% ± 28%	Explore
bone marrow	7 studies	47% ± 22%	Explore
liver	6 studies	46% ± 27%	Explore
intestine	5 studies	53% ± 25%	Explore
brain	5 studies	42% ± 22%	Explore
lymph node	5 studies	53% ± 19%	Explore
heart	4 studies	19% ± 1%	Explore
uterus	4 studies	38% ± 14%	Explore
breast	4 studies	36% ± 14%	Explore
adipose	3 studies	38% ± 23%	Explore
adrenal gland	3 studies	51% ± 28%	Explore
placenta	3 studies	34% ± 12%	Explore
thymus	3 studies	32% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	18988.39	578 / 578	97%	368.16	1116 / 1155
breast	99%	7585.45	455 / 459	93%	186.42	1045 / 1118
thymus	95%	4337.34	620 / 653	95%	161.10	576 / 605
kidney	87%	4508.16	77 / 89	90%	289.80	810 / 901
uterus	84%	3150.76	143 / 170	83%	158.08	383 / 459
prostate	81%	3294.64	198 / 245	86%	106.32	432 / 502
bladder	90%	4634.86	19 / 21	76%	195.47	382 / 504
intestine	84%	3605.22	809 / 966	79%	160.31	417 / 527
esophagus	58%	2104.67	838 / 1445	90%	175.84	165 / 183
adrenal gland	71%	2229.62	182 / 258	75%	121.16	172 / 230
stomach	61%	2173.54	218 / 359	83%	216.47	237 / 286
brain	45%	1948.26	1188 / 2642	96%	252.58	680 / 705
ovary	36%	1144.06	65 / 180	89%	172.39	382 / 430
skin	35%	1946.18	633 / 1809	85%	222.51	403 / 472
lymph node	0%	0	0 / 0	100%	1007.66	29 / 29
peripheral blood	100%	89794.16	929 / 929	0%	0	0 / 0
spleen	100%	19369.01	241 / 241	0%	0	0 / 0
adipose	100%	11623.77	1201 / 1204	0%	0	0 / 0
pancreas	7%	171.67	22 / 328	93%	290.54	165 / 178
blood vessel	97%	7116.66	1291 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	190.72	42 / 45
liver	30%	975.02	67 / 226	56%	72.98	229 / 406
heart	82%	3443.38	702 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	43%	39.07	34 / 80
muscle	20%	443.24	157 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0140507	Biological process	granzyme-mediated programmed cell death signaling pathway
GO_0033371	Biological process	T cell secretory granule organization
GO_0033363	Biological process	secretory granule organization
GO_0016485	Biological process	protein processing
GO_0033364	Biological process	mast cell secretory granule organization
GO_0031214	Biological process	biomineral tissue development
GO_0030502	Biological process	negative regulation of bone mineralization
GO_0033382	Biological process	maintenance of granzyme B location in T cell secretory granule
GO_0001818	Biological process	negative regulation of cytokine production
GO_0006915	Biological process	apoptotic process
GO_0033373	Biological process	maintenance of protease location in mast cell secretory granule
GO_0005615	Cellular component	extracellular space
GO_0044194	Cellular component	cytolytic granule
GO_0005576	Cellular component	extracellular region
GO_0042629	Cellular component	mast cell granule
GO_0005794	Cellular component	Golgi apparatus
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0030141	Cellular component	secretory granule
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SRGN
Protein name	Serglycin (Hematopoietic proteoglycan core protein) (Platelet proteoglycan core protein) (P.PG) (Secretory granule proteoglycan core protein)
Synonyms	PRG PRG1
Description	FUNCTION: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization. .
Accessions	ENST00000242465.4 P10124

SRGN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review