ZSWIM2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZSWIM2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZSWIM2 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_1902043Biological processpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0000209Biological processprotein polyubiquitination
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameZSWIM2
Protein nameE3 ubiquitin-protein ligase ZSWIM2 (EC 2.3.2.27) (MEKK1-related protein X) (MEX) (RING-type E3 ubiquitin transferase ZSWIM2) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2)
Zinc finger SWIM-type containing 2
SynonymsZZZ2
DescriptionFUNCTION: E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes. .

AccessionsENST00000419862.1
F8WCC6
ENST00000295131.3
Q8NEG5