MAGI3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006915Biological processapoptotic process
GO_0046037Biological processGMP metabolic process
GO_0035556Biological processintracellular signal transduction
GO_0046710Biological processGDP metabolic process
GO_0005911Cellular componentcell-cell junction
GO_0030054Cellular componentcell junction
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0005634Cellular componentnucleus
GO_0004385Molecular functionguanylate kinase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMAGI3
Protein nameMembrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)
SynonymsKIAA1634
DescriptionFUNCTION: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. .

AccessionsENST00000369617.8 [Q5TCQ9-2]
Q5TCQ9
ENST00000369611.4 [Q5TCQ9-3]
ENST00000369615.5 [Q5TCQ9-3]
ENST00000307546.14 [Q5TCQ9-4]