Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 38% ± 16% | |
astrocyte | 16 studies | 43% ± 18% | |
type I pneumocyte | 12 studies | 56% ± 27% | |
GABAergic neuron | 11 studies | 40% ± 20% | |
glutamatergic neuron | 11 studies | 54% ± 25% | |
oligodendrocyte precursor cell | 11 studies | 36% ± 14% | |
fibroblast | 11 studies | 29% ± 8% | |
epithelial cell | 10 studies | 31% ± 14% | |
microglial cell | 9 studies | 31% ± 16% | |
endothelial cell of lymphatic vessel | 8 studies | 30% ± 11% | |
pericyte | 8 studies | 25% ± 6% | |
smooth muscle cell | 8 studies | 22% ± 5% | |
type II pneumocyte | 7 studies | 56% ± 22% | |
club cell | 7 studies | 47% ± 24% | |
amacrine cell | 7 studies | 39% ± 20% | |
adipocyte | 7 studies | 23% ± 4% | |
neuron | 6 studies | 37% ± 18% | |
interneuron | 6 studies | 48% ± 25% | |
basal cell | 6 studies | 33% ± 16% | |
retinal bipolar neuron | 5 studies | 38% ± 17% | |
retinal ganglion cell | 5 studies | 37% ± 18% | |
retina horizontal cell | 5 studies | 44% ± 19% | |
ciliated cell | 5 studies | 36% ± 16% | |
macrophage | 4 studies | 24% ± 8% | |
progenitor cell | 4 studies | 31% ± 9% | |
cardiac muscle cell | 4 studies | 18% ± 2% | |
mesothelial cell | 4 studies | 37% ± 12% | |
Mueller cell | 4 studies | 46% ± 16% | |
retinal rod cell | 4 studies | 37% ± 14% | |
endothelial cell of vascular tree | 4 studies | 28% ± 10% | |
respiratory goblet cell | 4 studies | 46% ± 20% | |
GABAergic interneuron | 3 studies | 34% ± 0% | |
granule cell | 3 studies | 28% ± 3% | |
squamous epithelial cell | 3 studies | 43% ± 19% | |
GABAergic amacrine cell | 3 studies | 54% ± 17% | |
OFF-bipolar cell | 3 studies | 44% ± 25% | |
ON-bipolar cell | 3 studies | 45% ± 22% | |
glycinergic amacrine cell | 3 studies | 31% ± 7% | |
retinal cone cell | 3 studies | 34% ± 16% | |
rod bipolar cell | 3 studies | 70% ± 22% | |
plasma cell | 3 studies | 27% ± 4% | |
hepatocyte | 3 studies | 57% ± 16% | |
retinal pigment epithelial cell | 3 studies | 33% ± 17% | |
ependymal cell | 3 studies | 32% ± 17% | |
goblet cell | 3 studies | 38% ± 28% | |
oligodendrocyte | 3 studies | 35% ± 19% | |
mucus secreting cell | 3 studies | 42% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1400.46 | 459 / 459 | 98% | 24.98 | 1095 / 1118 |
esophagus | 100% | 1386.64 | 1445 / 1445 | 97% | 12.89 | 178 / 183 |
intestine | 100% | 1670.52 | 966 / 966 | 97% | 9.93 | 509 / 527 |
lung | 100% | 2093.42 | 577 / 578 | 97% | 13.70 | 1117 / 1155 |
prostate | 100% | 953.66 | 245 / 245 | 96% | 10.94 | 483 / 502 |
stomach | 100% | 1317.31 | 359 / 359 | 96% | 10.64 | 274 / 286 |
brain | 99% | 1333.14 | 2626 / 2642 | 95% | 10.99 | 672 / 705 |
thymus | 100% | 2382.92 | 653 / 653 | 93% | 17.70 | 565 / 605 |
pancreas | 100% | 1133.71 | 328 / 328 | 93% | 7.67 | 165 / 178 |
ovary | 100% | 1320.69 | 180 / 180 | 91% | 7.47 | 392 / 430 |
uterus | 100% | 1112.62 | 170 / 170 | 89% | 9.39 | 408 / 459 |
adrenal gland | 98% | 753.45 | 254 / 258 | 81% | 5.82 | 186 / 230 |
bladder | 100% | 888.52 | 21 / 21 | 77% | 6.29 | 388 / 504 |
skin | 99% | 764.23 | 1786 / 1809 | 64% | 3.95 | 302 / 472 |
kidney | 100% | 1012.81 | 89 / 89 | 62% | 4.66 | 557 / 901 |
liver | 97% | 548.93 | 219 / 226 | 57% | 3.97 | 232 / 406 |
adipose | 100% | 951.14 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 976.69 | 1333 / 1335 | 0% | 0 | 0 / 0 |
spleen | 98% | 450.20 | 236 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 14.59 | 42 / 45 |
heart | 90% | 517.82 | 775 / 861 | 0% | 0 | 0 / 0 |
muscle | 73% | 250.27 | 589 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 13% | 38.14 | 121 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 10% | 0.53 | 3 / 29 |
eye | 0% | 0 | 0 / 0 | 8% | 0.45 | 6 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007165 | Biological process | signal transduction |
GO_0006915 | Biological process | apoptotic process |
GO_0046037 | Biological process | GMP metabolic process |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0046710 | Biological process | GDP metabolic process |
GO_0005911 | Cellular component | cell-cell junction |
GO_0030054 | Cellular component | cell junction |
GO_0016020 | Cellular component | membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005923 | Cellular component | bicellular tight junction |
GO_0005634 | Cellular component | nucleus |
GO_0004385 | Molecular function | guanylate kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | MAGI3 |
Protein name | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3) |
Synonyms | KIAA1634 |
Description | FUNCTION: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. . |
Accessions | ENST00000369617.8 [Q5TCQ9-2] Q5TCQ9 ENST00000369611.4 [Q5TCQ9-3] ENST00000369615.5 [Q5TCQ9-3] ENST00000307546.14 [Q5TCQ9-4] |