AIFM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0002931Biological processresponse to ischemia
GO_0030261Biological processchromosome condensation
GO_0060545Biological processpositive regulation of necroptotic process
GO_0071392Biological processcellular response to estradiol stimulus
GO_0033108Biological processmitochondrial respiratory chain complex assembly
GO_0071732Biological processcellular response to nitric oxide
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0045041Biological processprotein import into mitochondrial intermembrane space
GO_0051402Biological processneuron apoptotic process
GO_1904045Biological processcellular response to aldosterone
GO_0006915Biological processapoptotic process
GO_0009636Biological processresponse to toxic substance
GO_0043065Biological processpositive regulation of apoptotic process
GO_1902065Biological processresponse to L-glutamate
GO_0070301Biological processcellular response to hydrogen peroxide
GO_1902510Biological processregulation of apoptotic DNA fragmentation
GO_0071456Biological processcellular response to hypoxia
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0071949Molecular functionFAD binding
GO_0003954Molecular functionNADH dehydrogenase activity
GO_0016174Molecular functionNAD(P)H oxidase H2O2-forming activity
GO_0072572Molecular functionpoly-ADP-D-ribose binding
GO_0016651Molecular functionoxidoreductase activity, acting on NAD(P)H
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAIFM1
Protein nameApoptosis inducing factor mitochondria associated 1
Alternative protein AIFM1
Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8)
SynonymsAIF
PDCD8
DescriptionFUNCTION: Functions both as NADH oxidoreductase and as regulator of apoptosis . In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway . Release into the cytoplasm is mediated upon binding to poly-ADP-ribose chains (By similarity). The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA . Binds to DNA in a sequence-independent manner . Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis . Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells . In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import . .; FUNCTION: [Isoform 4]: Has NADH oxidoreductase activity. Does not induce nuclear apoptosis. .; FUNCTION: [Isoform 5]: Pro-apoptotic isoform. .

AccessionsENST00000674997.1 [O95831-6]
ENST00000287295.8 [O95831-1]
A0A6Q8PFS4
A0A6Q8PGB7
A0A6Q8PFM5
ENST00000675037.1
ENST00000675774.1 [O95831-6]
ENST00000529877.1
ENST00000535724.6 [O95831-4]
ENST00000674546.1
A0A6Q8PFA7
ENST00000674555.1
ENST00000675857.1
ENST00000675092.1
L8E8P8
O95831
ENST00000319908.8
A0A6Q8PFQ8
ENST00000460436.6
ENST00000346424.6 [O95831-2]
A0A6Q8PG15
ENST00000676144.1
A0A7I2RLJ8
ENST00000675240.1
A0A6Q8PHC0
ENST00000675050.1 [O95831-3]
A0A6Q8PFW2
A0A6Q8PFN1
E9PMQ8
A0A6Q8PHJ9
A0A6Q8PHJ4
A0A7I2PK44
ENST00000527892.5 [O95831-6]
ENST00000676328.1
ENST00000674957.1
A0A6Q8PF87
ENST00000416073.7
E9PMA0
ENST00000674722.1
ENST00000675427.1
ENST00000676436.1
A0A6Q8PFE1
ENST00000674601.1
ENST00000676229.1 [O95831-3]