TRIM35 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM35 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM35 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0016567Biological processprotein ubiquitination
GO_0044790Biological processsuppression of viral release by host
GO_0045930Biological processnegative regulation of mitotic cell cycle
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045087Biological processinnate immune response
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameTRIM35
Protein nameTripartite motif containing 35
E3 ubiquitin-protein ligase TRIM35 (EC 2.3.2.27) (Hemopoietic lineage switch protein 5)
SynonymsHLS5
KIAA1098
DescriptionFUNCTION: E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway . Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 . Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway . Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth . .

AccessionsQ9UPQ4
H0YBF3
ENST00000305364.9 [Q9UPQ4-1]
E5RGB3
ENST00000521253.1
ENST00000521283.1