RALB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_2000786Biological processpositive regulation of autophagosome assembly
GO_0031623Biological processreceptor internalization
GO_0060178Biological processregulation of exocyst localization
GO_0032092Biological processpositive regulation of protein binding
GO_0007165Biological processsignal transduction
GO_0051301Biological processcell division
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0001928Biological processregulation of exocyst assembly
GO_0009267Biological processcellular response to starvation
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0006915Biological processapoptotic process
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0032091Biological processnegative regulation of protein binding
GO_0071902Biological processpositive regulation of protein serine/threonine kinase activity
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0019003Molecular functionGDP binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003925Molecular functionG protein activity
GO_0005525Molecular functionGTP binding
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRALB
Protein nameAlternative protein RALB
Ras-related protein Ral-B (EC 3.6.5.2)
RAS like proto-oncogene B
Synonyms
DescriptionFUNCTION: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking . Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis . In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission . Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors . .

AccessionsENST00000449649.1
F8WEQ6
ENST00000447591.5
ENST00000631312.2
P11234
C9JQB3
ENST00000412383.5
C9J6B1
ENST00000431732.5
C9JYR1
ENST00000272519.10 [P11234-1]
ENST00000420510.5 [P11234-1]
L8E7S5