PMAIP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	32 studies	30% ± 12%	Explore
natural killer cell	25 studies	29% ± 11%	Explore
regulatory T cell	22 studies	31% ± 11%	Explore
naive B cell	18 studies	29% ± 9%	Explore
memory B cell	18 studies	32% ± 11%	Explore
basal cell	17 studies	29% ± 10%	Explore
conventional dendritic cell	15 studies	29% ± 16%	Explore
CD8-positive, alpha-beta T cell	14 studies	28% ± 13%	Explore
dendritic cell	12 studies	42% ± 15%	Explore
T cell	11 studies	25% ± 8%	Explore
non-classical monocyte	10 studies	29% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	32% ± 14%	Explore
mature NK T cell	10 studies	22% ± 7%	Explore
macrophage	10 studies	23% ± 5%	Explore
epithelial cell	10 studies	39% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	29% ± 12%	Explore
CD4-positive, alpha-beta T cell	8 studies	25% ± 8%	Explore
endothelial cell	8 studies	25% ± 9%	Explore
secretory cell	8 studies	35% ± 13%	Explore
gamma-delta T cell	8 studies	33% ± 14%	Explore
leukocyte	6 studies	33% ± 8%	Explore
mucosal invariant T cell	6 studies	30% ± 13%	Explore
precursor B cell	6 studies	34% ± 11%	Explore
ciliated cell	6 studies	38% ± 21%	Explore
classical monocyte	5 studies	31% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	26% ± 8%	Explore
endothelial cell of vascular tree	5 studies	21% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	36% ± 10%	Explore
plasmacytoid dendritic cell	5 studies	29% ± 9%	Explore
monocyte	4 studies	25% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	23% ± 7%	Explore
mononuclear phagocyte	4 studies	30% ± 9%	Explore
pro-B cell	4 studies	34% ± 12%	Explore
myeloid cell	4 studies	35% ± 13%	Explore
immature B cell	4 studies	34% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	22% ± 2%	Explore
squamous epithelial cell	3 studies	43% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	20% ± 4%	Explore
exhausted T cell	3 studies	32% ± 9%	Explore
hematopoietic precursor cell	3 studies	32% ± 17%	Explore
plasmablast	3 studies	38% ± 17%	Explore
placental villous trophoblast	3 studies	30% ± 6%	Explore
plasma cell	3 studies	19% ± 2%	Explore
club cell	3 studies	32% ± 12%	Explore
double negative thymocyte	3 studies	50% ± 11%	Explore
germinal center B cell	3 studies	36% ± 7%	Explore
fibroblast	3 studies	16% ± 1%	Explore
luminal cell of prostate epithelium	3 studies	25% ± 4%	Explore
monocyte-derived dendritic cell	3 studies	32% ± 10%	Explore
keratinocyte	3 studies	60% ± 11%	Explore
progenitor cell of mammary luminal epithelium	3 studies	21% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	28% ± 10%	Explore
peripheral blood	5 studies	32% ± 12%	Explore
lymph node	4 studies	27% ± 10%	Explore
esophagus	3 studies	26% ± 7%	Explore
prostate	3 studies	30% ± 6%	Explore
skin	3 studies	32% ± 10%	Explore
breast	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	93%	338.81	540 / 578	93%	41.49	1073 / 1155
skin	100%	1305.76	1805 / 1809	77%	20.05	362 / 472
intestine	64%	177.73	618 / 966	91%	21.24	479 / 527
esophagus	51%	413.63	744 / 1445	96%	33.01	175 / 183
breast	58%	133.00	268 / 459	88%	32.46	986 / 1118
bladder	57%	139.57	12 / 21	87%	26.88	436 / 504
uterus	28%	66.49	47 / 170	95%	55.02	437 / 459
stomach	35%	107.24	127 / 359	86%	19.76	247 / 286
prostate	70%	171.36	172 / 245	40%	4.65	201 / 502
pancreas	18%	34.88	58 / 328	84%	15.74	150 / 178
lymph node	0%	0	0 / 0	100%	96.67	29 / 29
spleen	100%	348.94	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	67.11	45 / 45
brain	54%	127.41	1423 / 2642	38%	4.51	266 / 705
ovary	9%	13.40	17 / 180	80%	13.31	345 / 430
thymus	16%	28.00	106 / 653	62%	12.37	377 / 605
peripheral blood	71%	2571.05	664 / 929	0%	0	0 / 0
kidney	38%	73.57	34 / 89	27%	5.04	243 / 901
adipose	56%	118.77	671 / 1204	0%	0	0 / 0
muscle	29%	50.92	236 / 803	0%	0	0 / 0
adrenal gland	5%	8.54	14 / 258	23%	8.05	54 / 230
liver	4%	6.04	9 / 226	10%	2.06	41 / 406
heart	12%	20.01	104 / 861	0%	0	0 / 0
blood vessel	11%	22.66	146 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	5%	0.37	4 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0090200	Biological process	positive regulation of release of cytochrome c from mitochondria
GO_0043029	Biological process	T cell homeostasis
GO_0042149	Biological process	cellular response to glucose starvation
GO_0010498	Biological process	proteasomal protein catabolic process
GO_0051607	Biological process	defense response to virus
GO_0006974	Biological process	DNA damage response
GO_2001244	Biological process	positive regulation of intrinsic apoptotic signaling pathway
GO_1902043	Biological process	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0043280	Biological process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0043331	Biological process	response to dsRNA
GO_0072593	Biological process	reactive oxygen species metabolic process
GO_0043517	Biological process	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO_1902237	Biological process	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0097193	Biological process	intrinsic apoptotic signaling pathway
GO_0072332	Biological process	intrinsic apoptotic signaling pathway by p53 class mediator
GO_0010917	Biological process	negative regulation of mitochondrial membrane potential
GO_0001836	Biological process	release of cytochrome c from mitochondria
GO_0010907	Biological process	positive regulation of glucose metabolic process
GO_0006915	Biological process	apoptotic process
GO_0046902	Biological process	regulation of mitochondrial membrane permeability
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0071456	Biological process	cellular response to hypoxia
GO_0005739	Cellular component	mitochondrion
GO_0005829	Cellular component	cytosol
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0097136	Cellular component	Bcl-2 family protein complex
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PMAIP1
Protein name	Phorbol-12-myristate-13-acetate-induced protein 1 isoform 1 Phorbol-12-myristate-13-acetate-induced protein 1 isoform 2 Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)
Synonyms	NOXA
Description	FUNCTION: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. .
Accessions	A0A0S2Z4V2 Q13794 A0A0S2Z490 ENST00000269518.9 [Q13794-2] ENST00000316660.7 [Q13794-1]

PMAIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review