Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 8 studies | 24% ± 7% | |
ciliated cell | 8 studies | 24% ± 12% | |
astrocyte | 7 studies | 31% ± 15% | |
epithelial cell | 5 studies | 29% ± 11% | |
GABAergic neuron | 5 studies | 39% ± 17% | |
glutamatergic neuron | 4 studies | 50% ± 19% | |
interneuron | 4 studies | 43% ± 21% | |
oligodendrocyte | 4 studies | 30% ± 7% | |
oligodendrocyte precursor cell | 4 studies | 29% ± 11% | |
hematopoietic precursor cell | 3 studies | 18% ± 3% | |
neural crest cell | 3 studies | 22% ± 5% | |
B cell | 3 studies | 22% ± 4% | |
microglial cell | 3 studies | 19% ± 3% | |
fibroblast | 3 studies | 18% ± 3% | |
basal cell | 3 studies | 27% ± 7% | |
transit amplifying cell | 3 studies | 37% ± 18% | |
neuron | 3 studies | 25% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 656.44 | 1445 / 1445 | 100% | 8.79 | 183 / 183 |
uterus | 100% | 716.85 | 170 / 170 | 100% | 15.07 | 459 / 459 |
prostate | 100% | 654.76 | 245 / 245 | 100% | 6.43 | 501 / 502 |
breast | 100% | 657.40 | 458 / 459 | 100% | 10.04 | 1116 / 1118 |
ovary | 100% | 893.26 | 180 / 180 | 100% | 8.63 | 428 / 430 |
thymus | 100% | 598.24 | 652 / 653 | 100% | 8.91 | 603 / 605 |
lung | 99% | 485.00 | 574 / 578 | 100% | 8.19 | 1155 / 1155 |
bladder | 100% | 562.38 | 21 / 21 | 99% | 10.06 | 499 / 504 |
adrenal gland | 100% | 586.71 | 258 / 258 | 98% | 6.55 | 225 / 230 |
intestine | 100% | 588.50 | 966 / 966 | 97% | 8.39 | 512 / 527 |
stomach | 99% | 417.69 | 355 / 359 | 98% | 8.25 | 280 / 286 |
pancreas | 98% | 353.88 | 321 / 328 | 98% | 6.40 | 175 / 178 |
brain | 99% | 374.25 | 2613 / 2642 | 95% | 6.70 | 669 / 705 |
kidney | 99% | 565.67 | 88 / 89 | 94% | 6.91 | 851 / 901 |
skin | 100% | 656.83 | 1805 / 1809 | 92% | 8.56 | 432 / 472 |
liver | 80% | 182.06 | 181 / 226 | 84% | 4.54 | 342 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 11.33 | 29 / 29 |
spleen | 100% | 659.67 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 12.88 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.22 | 1 / 1 |
adipose | 100% | 497.62 | 1202 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 468.99 | 1323 / 1335 | 0% | 0 | 0 / 0 |
heart | 93% | 286.93 | 798 / 861 | 0% | 0 | 0 / 0 |
muscle | 86% | 199.44 | 690 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 57% | 2.71 | 46 / 80 |
peripheral blood | 52% | 508.99 | 481 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0006915 | Biological process | apoptotic process |
GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
GO_0051301 | Biological process | cell division |
GO_0007155 | Biological process | cell adhesion |
GO_0034080 | Biological process | CENP-A containing chromatin assembly |
GO_0007059 | Biological process | chromosome segregation |
GO_1904036 | Biological process | negative regulation of epithelial cell apoptotic process |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0016020 | Cellular component | membrane |
GO_0000939 | Cellular component | inner kinetochore |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
Gene name | ITGB3BP |
Protein name | Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3) |
Synonyms | NRIF3 CENPR |
Description | FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. . |
Accessions | Q13352 ENST00000271002.15 [Q13352-1] ENST00000371092.7 [Q13352-5] ENST00000489099.5 [Q13352-2] |