ITGB3BP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006915Biological processapoptotic process
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0051301Biological processcell division
GO_0007155Biological processcell adhesion
GO_0034080Biological processCENP-A containing chromatin assembly
GO_0007059Biological processchromosome segregation
GO_1904036Biological processnegative regulation of epithelial cell apoptotic process
GO_0006355Biological processregulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0000939Cellular componentinner kinetochore
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameITGB3BP
Protein nameCentromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3)
SynonymsNRIF3
CENPR
DescriptionFUNCTION: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. .

AccessionsQ13352
ENST00000271002.15 [Q13352-1]
ENST00000371092.7 [Q13352-5]
ENST00000489099.5 [Q13352-2]