I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| transit amplifying cell | 3 studies | 23% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| transit amplifying cell | 3 studies | 23% ± 8% |
Insufficient scRNA-seq data for expression of BUB1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 95% | 1232.23 | 1717 / 1809 | 93% | 19.02 | 440 / 472 |
| lung | 86% | 229.84 | 498 / 578 | 91% | 18.04 | 1049 / 1155 |
| intestine | 55% | 255.92 | 536 / 966 | 97% | 21.73 | 509 / 527 |
| stomach | 51% | 177.26 | 183 / 359 | 98% | 22.26 | 280 / 286 |
| bladder | 52% | 80.95 | 11 / 21 | 95% | 20.72 | 478 / 504 |
| esophagus | 45% | 295.78 | 654 / 1445 | 99% | 26.41 | 181 / 183 |
| ovary | 31% | 70.66 | 55 / 180 | 97% | 19.71 | 418 / 430 |
| uterus | 28% | 32.39 | 48 / 170 | 98% | 24.03 | 449 / 459 |
| breast | 35% | 41.69 | 161 / 459 | 89% | 16.44 | 996 / 1118 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 32.25 | 29 / 29 |
| spleen | 100% | 1000.95 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 23.10 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.05 | 1 / 1 |
| pancreas | 8% | 9.71 | 27 / 328 | 71% | 7.64 | 126 / 178 |
| peripheral blood | 79% | 2365.01 | 730 / 929 | 0% | 0 | 0 / 0 |
| adrenal gland | 47% | 70.38 | 122 / 258 | 21% | 2.33 | 48 / 230 |
| liver | 18% | 42.70 | 41 / 226 | 40% | 3.60 | 163 / 406 |
| brain | 8% | 7.57 | 211 / 2642 | 43% | 6.08 | 303 / 705 |
| thymus | 24% | 36.98 | 156 / 653 | 22% | 4.57 | 132 / 605 |
| prostate | 28% | 36.09 | 69 / 245 | 17% | 1.30 | 87 / 502 |
| kidney | 26% | 57.28 | 23 / 89 | 17% | 1.62 | 156 / 901 |
| adipose | 34% | 50.51 | 413 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 31% | 2.01 | 25 / 80 |
| heart | 24% | 27.59 | 204 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 21% | 25.11 | 281 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 3% | 3.27 | 26 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_2000720 | Biological process | positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0007063 | Biological process | regulation of sister chromatid cohesion |
| GO_0051301 | Biological process | cell division |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0051754 | Biological process | meiotic sister chromatid cohesion, centromeric |
| GO_0051983 | Biological process | regulation of chromosome segregation |
| GO_0006915 | Biological process | apoptotic process |
| GO_0007094 | Biological process | mitotic spindle assembly checkpoint signaling |
| GO_0016020 | Cellular component | membrane |
| GO_0000776 | Cellular component | kinetochore |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0000940 | Cellular component | outer kinetochore |
| GO_0005634 | Cellular component | nucleus |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0140995 | Molecular function | histone H2A kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | BUB1 |
| Protein name | Mitotic spindle checkpoint kinase Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) BUB1 mitotic checkpoint serine/threonine kinase BUB1 protein |
| Synonyms | BUB1L |
| Description | FUNCTION: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A . Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. . |
| Accessions | O43683 ENST00000447014.5 ENST00000671097.1 ENST00000409311.5 [O43683-2] ENST00000420328.5 Q9BXX5 ENST00000302759.11 [O43683-1] A0A590UK50 A0A590UJ99 C9JQA4 C9IYH4 C9JRC7 ENST00000666956.1 ENST00000436916.1 ENST00000535254.6 [O43683-3] A0JLU2 |
