PEG10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0051260Biological processprotein homooligomerization
GO_0030154Biological processcell differentiation
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0110077Biological processvesicle-mediated intercellular transport
GO_0051028Biological processmRNA transport
GO_1903561Cellular componentextracellular vesicle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePEG10
Protein nameRetrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation-regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein)
Paternally expressed 10
Retrotransposon-derived protein PEG10
SynonymsEDR
MART2
RGAG3
MEF3L1
KIAA1051e
MAR2
DescriptionFUNCTION: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids . Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA . Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region . Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 . Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 . May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity). .

AccessionsENST00000615790
ENST00000612748.1
ENST00000613043.1
A0A087WXK2
ENST00000617526.4
ENST00000612941.2
A0A087WX23
ENST00000482108.1 [Q86TG7-2]
A0A087WZG9
ENST00000488574.5 [Q86TG7-5]
A0A087WYS2
Q86TG7
A0A087WUL4
ENST00000615790.5 [Q86TG7-3]