Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 8 studies | 33% ± 10% | |
connective tissue cell | 7 studies | 34% ± 12% | |
neuron | 7 studies | 35% ± 23% | |
type I pneumocyte | 6 studies | 27% ± 9% | |
endothelial cell | 6 studies | 25% ± 8% | |
abnormal cell | 5 studies | 38% ± 19% | |
epithelial cell | 5 studies | 27% ± 7% | |
GABAergic neuron | 5 studies | 29% ± 7% | |
glutamatergic neuron | 5 studies | 29% ± 13% | |
type II pneumocyte | 4 studies | 29% ± 3% | |
pancreatic A cell | 4 studies | 41% ± 19% | |
pericyte | 4 studies | 29% ± 12% | |
retinal ganglion cell | 4 studies | 44% ± 21% | |
smooth muscle cell | 4 studies | 18% ± 3% | |
pancreatic D cell | 3 studies | 46% ± 23% | |
myofibroblast cell | 3 studies | 22% ± 1% | |
neural crest cell | 3 studies | 40% ± 30% | |
progenitor cell | 3 studies | 18% ± 4% | |
retinal bipolar neuron | 3 studies | 25% ± 6% | |
placental villous trophoblast | 3 studies | 87% ± 16% | |
amacrine cell | 3 studies | 22% ± 6% | |
Mueller cell | 3 studies | 36% ± 13% | |
basal cell | 3 studies | 22% ± 4% | |
interneuron | 3 studies | 44% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 98% | 17647.29 | 2594 / 2642 | 94% | 106.49 | 664 / 705 |
ovary | 97% | 8212.63 | 175 / 180 | 84% | 67.98 | 362 / 430 |
adrenal gland | 100% | 58503.66 | 258 / 258 | 81% | 135.65 | 186 / 230 |
lung | 68% | 3384.98 | 391 / 578 | 47% | 52.10 | 546 / 1155 |
skin | 24% | 1200.70 | 431 / 1809 | 79% | 91.04 | 371 / 472 |
breast | 34% | 913.38 | 156 / 459 | 61% | 128.12 | 677 / 1118 |
bladder | 52% | 1100.76 | 11 / 21 | 22% | 21.25 | 111 / 504 |
uterus | 26% | 535.71 | 45 / 170 | 39% | 45.60 | 178 / 459 |
kidney | 17% | 369.08 | 15 / 89 | 44% | 18.37 | 398 / 901 |
thymus | 7% | 121.73 | 44 / 653 | 52% | 23.99 | 317 / 605 |
intestine | 44% | 1183.47 | 423 / 966 | 11% | 6.51 | 57 / 527 |
pancreas | 12% | 195.13 | 39 / 328 | 34% | 19.86 | 61 / 178 |
liver | 4% | 78.11 | 8 / 226 | 35% | 84.71 | 143 / 406 |
stomach | 23% | 769.97 | 84 / 359 | 15% | 11.08 | 43 / 286 |
esophagus | 4% | 84.46 | 64 / 1445 | 27% | 20.44 | 49 / 183 |
eye | 0% | 0 | 0 / 0 | 25% | 9.96 | 20 / 80 |
lymph node | 0% | 0 | 0 / 0 | 24% | 13.18 | 7 / 29 |
tonsil | 0% | 0 | 0 / 0 | 22% | 12.58 | 10 / 45 |
blood vessel | 16% | 293.84 | 215 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 16% | 733.71 | 146 / 929 | 0% | 0 | 0 / 0 |
adipose | 11% | 216.03 | 132 / 1204 | 0% | 0 | 0 / 0 |
prostate | 2% | 27.88 | 4 / 245 | 3% | 1.98 | 15 / 502 |
muscle | 3% | 60.40 | 28 / 803 | 0% | 0 | 0 / 0 |
heart | 1% | 9.95 | 5 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006915 | Biological process | apoptotic process |
GO_0051260 | Biological process | protein homooligomerization |
GO_0030154 | Biological process | cell differentiation |
GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
GO_0110077 | Biological process | vesicle-mediated intercellular transport |
GO_0051028 | Biological process | mRNA transport |
GO_1903561 | Cellular component | extracellular vesicle |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0003677 | Molecular function | DNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0003729 | Molecular function | mRNA binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | PEG10 |
Protein name | Retrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation-regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein) Paternally expressed 10 Retrotransposon-derived protein PEG10 |
Synonyms | EDR MART2 RGAG3 MEF3L1 KIAA1051e MAR2 |
Description | FUNCTION: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids . Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA . Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region . Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 . Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 . May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity). . |
Accessions | ENST00000615790 ENST00000612748.1 ENST00000613043.1 A0A087WXK2 ENST00000617526.4 ENST00000612941.2 A0A087WX23 ENST00000482108.1 [Q86TG7-2] A0A087WZG9 ENST00000488574.5 [Q86TG7-5] A0A087WYS2 Q86TG7 A0A087WUL4 ENST00000615790.5 [Q86TG7-3] |