I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 11 studies | 37% ± 18% | |
| melanocyte | 5 studies | 48% ± 22% | |
| epithelial cell of proximal tubule | 3 studies | 23% ± 7% | |
| type II pneumocyte | 3 studies | 20% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 11 studies | 37% ± 18% | |
| melanocyte | 5 studies | 48% ± 22% | |
| epithelial cell of proximal tubule | 3 studies | 23% ± 7% | |
| type II pneumocyte | 3 studies | 20% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 24% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 87% | 2242.90 | 1580 / 1809 | 80% | 6.59 | 376 / 472 |
| brain | 99% | 4825.94 | 2613 / 2642 | 63% | 1.75 | 446 / 705 |
| kidney | 100% | 3910.76 | 89 / 89 | 45% | 1.13 | 401 / 901 |
| thymus | 99% | 1918.39 | 647 / 653 | 43% | 0.98 | 260 / 605 |
| esophagus | 98% | 1779.58 | 1417 / 1445 | 35% | 0.66 | 64 / 183 |
| lung | 100% | 3425.41 | 576 / 578 | 32% | 0.85 | 364 / 1155 |
| intestine | 99% | 2164.27 | 961 / 966 | 18% | 0.31 | 97 / 527 |
| bladder | 100% | 1714.14 | 21 / 21 | 17% | 0.37 | 88 / 504 |
| uterus | 100% | 2351.26 | 170 / 170 | 17% | 0.31 | 80 / 459 |
| ovary | 100% | 2311.93 | 180 / 180 | 14% | 0.23 | 60 / 430 |
| prostate | 100% | 2561.86 | 244 / 245 | 12% | 0.18 | 60 / 502 |
| liver | 97% | 2273.57 | 219 / 226 | 14% | 0.27 | 58 / 406 |
| breast | 99% | 2064.98 | 455 / 459 | 11% | 0.20 | 121 / 1118 |
| muscle | 100% | 38244.98 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2950.89 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 2054.34 | 1320 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 1765.70 | 1186 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 14.34 | 77 / 80 |
| adrenal gland | 92% | 1185.64 | 238 / 258 | 2% | 0.03 | 5 / 230 |
| stomach | 77% | 1009.18 | 276 / 359 | 15% | 0.27 | 44 / 286 |
| pancreas | 56% | 524.41 | 185 / 328 | 31% | 0.49 | 55 / 178 |
| peripheral blood | 85% | 1328.88 | 791 / 929 | 0% | 0 | 0 / 0 |
| heart | 84% | 1137.50 | 726 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 0.24 | 5 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 0.19 | 5 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1990092 | Biological process | calcium-dependent self proteolysis |
| GO_0046716 | Biological process | muscle cell cellular homeostasis |
| GO_0045862 | Biological process | positive regulation of proteolysis |
| GO_0061061 | Biological process | muscle structure development |
| GO_0031648 | Biological process | protein destabilization |
| GO_0014718 | Biological process | positive regulation of satellite cell activation involved in skeletal muscle regeneration |
| GO_0014850 | Biological process | response to muscle activity |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0071277 | Biological process | cellular response to calcium ion |
| GO_0033234 | Biological process | negative regulation of protein sumoylation |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0097264 | Biological process | self proteolysis |
| GO_0006508 | Biological process | proteolysis |
| GO_0030239 | Biological process | myofibril assembly |
| GO_0007517 | Biological process | muscle organ development |
| GO_0071472 | Biological process | cellular response to salt stress |
| GO_0030163 | Biological process | protein catabolic process |
| GO_0070315 | Biological process | G1 to G0 transition involved in cell differentiation |
| GO_0050790 | Biological process | regulation of catalytic activity |
| GO_0006915 | Biological process | apoptotic process |
| GO_0051281 | Biological process | positive regulation of release of sequestered calcium ion into cytosol |
| GO_0045214 | Biological process | sarcomere organization |
| GO_0043122 | Biological process | regulation of canonical NF-kappaB signal transduction |
| GO_0045661 | Biological process | regulation of myoblast differentiation |
| GO_0072657 | Biological process | protein localization to membrane |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0051592 | Biological process | response to calcium ion |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030018 | Cellular component | Z disc |
| GO_0030016 | Cellular component | myofibril |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0030315 | Cellular component | T-tubule |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0008233 | Molecular function | peptidase activity |
| GO_0008307 | Molecular function | structural constituent of muscle |
| GO_0060090 | Molecular function | molecular adaptor activity |
| GO_0031432 | Molecular function | titin binding |
| GO_0003824 | Molecular function | catalytic activity |
| GO_0004198 | Molecular function | calcium-dependent cysteine-type endopeptidase activity |
| GO_0055103 | Molecular function | ligase regulator activity |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0008234 | Molecular function | cysteine-type peptidase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0031402 | Molecular function | sodium ion binding |
| Gene name | CAPN3 |
| Protein name | Calpain 3 Calpain 3 isoform 1 Calpain-3 (EC 3.4.22.54) CAPN3 protein Calpain 3, (P94) Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1) Calpain 3 isoform 7 HUp12 |
| Synonyms | CANPL3 NCL1 CANP3 |
| Description | FUNCTION: Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53 . . FUNCTION: Calcium-regulated non-lysosomal thiol-protease. . FUNCTION: Calcium-regulated non-lysosomal thiol-protease. . FUNCTION: Calcium-regulated non-lysosomal thiol-protease. . FUNCTION: Calcium-regulated non-lysosomal thiol-protease. . FUNCTION: Calcium-regulated non-lysosomal thiol-protease. . FUNCTION: Calcium-regulated non-lysosomal thiol-protease. . FUNCTION: Calcium-regulated non-lysosomal thiol-protease. . |
| Accessions | Q496N2 A0A669KBE1 H3BMH1 ENST00000673939.1 A0A669KAX6 ENST00000561817.5 H3BS77 ENST00000565274.5 ENST00000674018.1 [P20807-5] H3BUZ3 ENST00000564503.5 ENST00000568153.2 F8W8F5 A0A669KAB9 ENST00000673771.1 [P20807-5] A0A0S2Z3E5 ENST00000674052.1 P20807 ENST00000567817.6 ENST00000674146.1 [P20807-5] H3BSA2 ENST00000673743.1 ENST00000397204.9 [P20807-5] Q762C8 A0A669KB02 A0A669KB08 A0A669KBA3 Q762C7 ENST00000673978.1 ENST00000673936.1 [P20807-5] ENST00000567071.5 H3BS30 ENST00000673851.1 [P20807-5] ENST00000349748.8 [P20807-2] ENST00000673646.1 A0A669KB98 ENST00000674011.1 ENST00000569136.6 [P20807-5] ENST00000674139.1 [P20807-5] ENST00000337571.9 [P20807-5] ENST00000673928.1 [P20807-5] ENST00000318023.11 ENST00000673750.1 A0A669KAU4 ENST00000673705.1 ENST00000673987.1 ENST00000674119.1 [P20807-5] ENST00000673890.1 [P20807-5] C6EVS4 ENST00000562199.2 ENST00000569827.5 H3BUR3 ENST00000673692.1 [P20807-5] ENST00000397163.8 [P20807-1] C6EVS3 A0A669KAU6 ENST00000357568.8 [P20807-3] A0A0S2Z3E1 A0A669KB11 ENST00000673886.1 [P20807-5] ENST00000674135.1 ENST00000673839.1 A4FTZ9 ENST00000397200.8 [P20807-4] H3BNN7 ENST00000673893.1 ENST00000565559.5 ENST00000674093.1 [P20807-5] H3BV08 Q762C6 A0A0S2Z3E6 ENST00000674149.1 [P20807-5] ENST00000674041.1 |
