NOX5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NOX5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NOX5 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0042554Biological processsuperoxide anion generation
GO_0061640Biological processcytoskeleton-dependent cytokinesis
GO_0001935Biological processendothelial cell proliferation
GO_0006915Biological processapoptotic process
GO_0043012Biological processregulation of fusion of sperm to egg plasma membrane
GO_0001819Biological processpositive regulation of cytokine production
GO_1902600Biological processproton transmembrane transport
GO_0006952Biological processdefense response
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043020Cellular componentNADPH oxidase complex
GO_0106292Molecular functionsuperoxide-generating NADPH oxidase activity
GO_0050660Molecular functionflavin adenine dinucleotide binding
GO_0015252Molecular functionproton channel activity
GO_0050661Molecular functionNADP binding
GO_0020037Molecular functionheme binding
GO_0016175Molecular functionsuperoxide-generating NAD(P)H oxidase activity
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene nameNOX5
Protein nameNADPH oxidase 5 (EC 1.6.3.-)
HCG2003451, isoform CRA_d (NOX5 variant lacking EF hands)
NADPH oxidase 5
SynonymshCG_2003451
DescriptionFUNCTION: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor . May play a role in cell growth and apoptosis . .; FUNCTION: [Isoform v2]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor . Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa . Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin . .; FUNCTION: [Isoform v1]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. .; FUNCTION: [Isoform v5]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor . According to PubMed:22427510, lacks enzyme activity . Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin . .; FUNCTION: [Isoform v4]: Lacks calcium-dependent NADPH oxidase activity. .; FUNCTION: [Isoform v3]: Lacks calcium-dependent NADPH oxidase activity. .

AccessionsENST00000525143.5
ENST00000388866.8 [Q96PH1-1]
A0A0B4J289
ENST00000530406.7 [Q96PH1-3]
A3QRJ0
Q96PH1