TGFBR1 | OmnibusX

Name	Number of supported studies	Average coverage
microglial cell	15 studies	44% ± 18%	Explore
macrophage	12 studies	30% ± 15%	Explore
myeloid cell	8 studies	27% ± 9%	Explore
endothelial cell	5 studies	23% ± 7%	Explore
dendritic cell	5 studies	20% ± 5%	Explore
natural killer cell	4 studies	24% ± 7%	Explore
neuron	4 studies	25% ± 6%	Explore
monocyte	4 studies	30% ± 11%	Explore
glutamatergic neuron	4 studies	27% ± 12%	Explore
oligodendrocyte precursor cell	4 studies	25% ± 8%	Explore
smooth muscle cell	4 studies	21% ± 6%	Explore
myofibroblast cell	3 studies	21% ± 4%	Explore
epithelial cell	3 studies	18% ± 3%	Explore
lymphocyte	3 studies	26% ± 6%	Explore
alveolar macrophage	3 studies	27% ± 9%	Explore
fibroblast	3 studies	20% ± 3%	Explore
GABAergic neuron	3 studies	26% ± 10%	Explore
astrocyte	3 studies	24% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	21% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4035.13	578 / 578	100%	33.96	1150 / 1155
esophagus	100%	3193.16	1445 / 1445	99%	43.17	182 / 183
kidney	100%	1873.76	89 / 89	99%	40.53	892 / 901
breast	100%	2689.40	459 / 459	99%	46.12	1103 / 1118
uterus	100%	3992.84	170 / 170	98%	33.46	450 / 459
prostate	100%	3341.60	244 / 245	98%	25.79	493 / 502
thymus	100%	2085.48	651 / 653	98%	56.17	593 / 605
intestine	100%	4609.85	965 / 966	97%	26.06	512 / 527
stomach	100%	5011.31	359 / 359	95%	29.10	272 / 286
skin	98%	2436.54	1771 / 1809	96%	52.84	454 / 472
bladder	100%	3720.81	21 / 21	93%	27.59	470 / 504
pancreas	94%	1259.77	307 / 328	98%	42.03	175 / 178
ovary	99%	2493.41	179 / 180	92%	14.40	396 / 430
adrenal gland	100%	1515.60	257 / 258	89%	31.34	205 / 230
brain	83%	1287.31	2186 / 2642	99%	35.53	700 / 705
liver	99%	1240.34	223 / 226	79%	13.44	322 / 406
adipose	100%	2854.57	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6642.22	1335 / 1335	0%	0	0 / 0
spleen	100%	2853.98	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.45	45 / 45
ureter	0%	0	0 / 0	100%	12.60	1 / 1
muscle	98%	1313.44	783 / 803	0%	0	0 / 0
peripheral blood	96%	2946.92	892 / 929	0%	0	0 / 0
heart	94%	1448.25	811 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	16.95	27 / 29
eye	0%	0	0 / 0	75%	17.79	60 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048870	Biological process	cell motility
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0060978	Biological process	angiogenesis involved in coronary vascular morphogenesis
GO_0036446	Biological process	myofibroblast differentiation
GO_0032331	Biological process	negative regulation of chondrocyte differentiation
GO_0060021	Biological process	roof of mouth development
GO_0060982	Biological process	coronary artery morphogenesis
GO_0046847	Biological process	filopodium assembly
GO_0048701	Biological process	embryonic cranial skeleton morphogenesis
GO_0001501	Biological process	skeletal system development
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_2001235	Biological process	positive regulation of apoptotic signaling pathway
GO_0006468	Biological process	protein phosphorylation
GO_0051726	Biological process	regulation of cell cycle
GO_1905007	Biological process	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO_0060037	Biological process	pharyngeal system development
GO_0070723	Biological process	response to cholesterol
GO_0001701	Biological process	in utero embryonic development
GO_0060017	Biological process	parathyroid gland development
GO_0007165	Biological process	signal transduction
GO_0010628	Biological process	positive regulation of gene expression
GO_0001822	Biological process	kidney development
GO_0060391	Biological process	positive regulation of SMAD protein signal transduction
GO_0003223	Biological process	ventricular compact myocardium morphogenesis
GO_1904018	Biological process	positive regulation of vasculature development
GO_0031396	Biological process	regulation of protein ubiquitination
GO_0042060	Biological process	wound healing
GO_1901203	Biological process	positive regulation of extracellular matrix assembly
GO_0001937	Biological process	negative regulation of endothelial cell proliferation
GO_0051491	Biological process	positive regulation of filopodium assembly
GO_0043542	Biological process	endothelial cell migration
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0060412	Biological process	ventricular septum morphogenesis
GO_0003342	Biological process	proepicardium development
GO_0043062	Biological process	extracellular structure organization
GO_0030336	Biological process	negative regulation of cell migration
GO_0007399	Biological process	nervous system development
GO_0048705	Biological process	skeletal system morphogenesis
GO_0051496	Biological process	positive regulation of stress fiber assembly
GO_1902462	Biological process	positive regulation of mesenchymal stem cell proliferation
GO_0071363	Biological process	cellular response to growth factor stimulus
GO_0042118	Biological process	endothelial cell activation
GO_1905223	Biological process	epicardium morphogenesis
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0048538	Biological process	thymus development
GO_0009952	Biological process	anterior/posterior pattern specification
GO_0008584	Biological process	male gonad development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0030199	Biological process	collagen fibril organization
GO_0010717	Biological process	regulation of epithelial to mesenchymal transition
GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0048844	Biological process	artery morphogenesis
GO_0032924	Biological process	activin receptor signaling pathway
GO_0001837	Biological process	epithelial to mesenchymal transition
GO_0009791	Biological process	post-embryonic development
GO_0030307	Biological process	positive regulation of cell growth
GO_0007507	Biological process	heart development
GO_0048663	Biological process	neuron fate commitment
GO_0048762	Biological process	mesenchymal cell differentiation
GO_0060317	Biological process	cardiac epithelial to mesenchymal transition
GO_0060043	Biological process	regulation of cardiac muscle cell proliferation
GO_0035556	Biological process	intracellular signal transduction
GO_0001938	Biological process	positive regulation of endothelial cell proliferation
GO_0030335	Biological process	positive regulation of cell migration
GO_0001935	Biological process	endothelial cell proliferation
GO_2001237	Biological process	negative regulation of extrinsic apoptotic signaling pathway
GO_0010718	Biological process	positive regulation of epithelial to mesenchymal transition
GO_0002088	Biological process	lens development in camera-type eye
GO_0006915	Biological process	apoptotic process
GO_0001824	Biological process	blastocyst development
GO_1905075	Biological process	positive regulation of tight junction disassembly
GO_0003222	Biological process	ventricular trabecula myocardium morphogenesis
GO_0008354	Biological process	germ cell migration
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0045121	Cellular component	membrane raft
GO_0009986	Cellular component	cell surface
GO_0005923	Cellular component	bicellular tight junction
GO_0005768	Cellular component	endosome
GO_0048179	Cellular component	activin receptor complex
GO_0005634	Cellular component	nucleus
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0070021	Cellular component	transforming growth factor beta ligand-receptor complex
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0004672	Molecular function	protein kinase activity
GO_0005524	Molecular function	ATP binding
GO_0016361	Molecular function	activin receptor activity, type I
GO_0050431	Molecular function	transforming growth factor beta binding
GO_0004675	Molecular function	transmembrane receptor protein serine/threonine kinase activity
GO_0046872	Molecular function	metal ion binding
GO_0046332	Molecular function	SMAD binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0048185	Molecular function	activin binding
GO_0005114	Molecular function	type II transforming growth factor beta receptor binding
GO_0005025	Molecular function	transforming growth factor beta receptor activity, type I
GO_0005515	Molecular function	protein binding
GO_0019838	Molecular function	growth factor binding
GO_0005024	Molecular function	transforming growth factor beta receptor activity
GO_0070411	Molecular function	I-SMAD binding

IV. Literature review

[source]

Gene name	TGFBR1
Protein name	Transforming growth factor beta receptor 1 TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) Mutant transforming growth factor beta receptor I TGF-beta receptor type-1 (EC 2.7.11.30) (Transforming growth factor-beta receptor type I)
Synonyms	hCG_30154 SKR4 ALK5
Description	FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation. .
Accessions	P36897 ENST00000698942.1 ENST00000552573.7 Q5T7S2 H0YHS4 ENST00000549021.6 F8VXZ5 ENST00000550253.1 ENST00000552516.5 [P36897-2] A0A8V8TMI6 ENST00000547314.6 F8W0K6 F8W1R9 A6MIV7 ENST00000698941.1 B4DY26 F8VRH6 ENST00000374990.6 [P36897-3] ENST00000546584.1 ENST00000548365.6 ENST00000549766.5 A6MIV6 ENST00000374994.9 [P36897-1]

TGFBR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review