TRIM69 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0016567Biological processprotein ubiquitination
GO_0071539Biological processprotein localization to centrosome
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameTRIM69
Protein nameE3 ubiquitin-protein ligase TRIM69 (Tripartite motif containing 69)
E3 ubiquitin-protein ligase TRIM69
E3 ubiquitin-protein ligase TRIM69 (EC 2.3.2.27) (RFP-like domain-containing protein trimless) (RING finger protein 36) (RING-type E3 ubiquitin transferase TRIM69) (Tripartite motif-containing protein 69)
SynonymsHSD34
HSD-34
RNF36
DescriptionFUNCTION: E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus . Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection . In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity . Plays also a role in cataract formation together with TP53 . Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination . Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1 . .

AccessionsQ86WT6
ENST00000559390.5 [Q86WT6-1]
ENST00000558329.5 [Q86WT6-4]
ENST00000560442.5 [Q86WT6-3]
H0YKB8
ENST00000621836.3
ENST00000633414.1
ENST00000618398.2 [Q86WT6-2]
ENST00000633859.1
ENST00000633106.1 [Q86WT6-3]
ENST00000329464.9 [Q86WT6-1]
ENST00000561170.1
ENST00000631458.1
H0YL66
ENST00000561043.5
A0A0G2JPI4
ENST00000338264.8 [Q86WT6-2]
ENST00000631740.1 [Q86WT6-4]