TNFRSF11B | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNFRSF11B at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	1762.54	89 / 89	90%	81.49	811 / 901
thymus	100%	4023.22	650 / 653	81%	48.79	490 / 605
lung	83%	1180.86	482 / 578	46%	9.00	527 / 1155
liver	62%	414.54	141 / 226	44%	14.54	178 / 406
blood vessel	97%	11033.07	1294 / 1335	0%	0	0 / 0
pancreas	4%	22.50	14 / 328	79%	31.61	141 / 178
intestine	8%	30.05	74 / 966	75%	24.16	395 / 527
breast	24%	122.56	108 / 459	46%	9.95	511 / 1118
ovary	1%	3.81	2 / 180	66%	18.44	285 / 430
stomach	2%	9.19	7 / 359	65%	19.22	187 / 286
adrenal gland	48%	365.43	124 / 258	12%	1.10	27 / 230
adipose	59%	353.07	705 / 1204	0%	0	0 / 0
skin	28%	935.69	500 / 1809	24%	6.03	111 / 472
esophagus	1%	3.19	12 / 1445	46%	13.12	85 / 183
brain	12%	60.02	306 / 2642	32%	5.70	226 / 705
bladder	0%	0	0 / 21	42%	10.77	214 / 504
lymph node	0%	0	0 / 0	31%	3.53	9 / 29
heart	29%	314.95	250 / 861	0%	0	0 / 0
uterus	9%	36.48	16 / 170	19%	6.93	87 / 459
prostate	7%	37.69	17 / 245	9%	0.83	45 / 502
tonsil	0%	0	0 / 0	13%	2.02	6 / 45
peripheral blood	2%	9.56	14 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.15	1 / 80
spleen	1%	4.94	3 / 241	0%	0	0 / 0
muscle	1%	3.05	7 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007584	Biological process	response to nutrient
GO_0043627	Biological process	response to estrogen
GO_0042489	Biological process	negative regulation of odontogenesis of dentin-containing tooth
GO_0032026	Biological process	response to magnesium ion
GO_0045779	Biological process	negative regulation of bone resorption
GO_0007165	Biological process	signal transduction
GO_0030198	Biological process	extracellular matrix organization
GO_0046685	Biological process	response to arsenic-containing substance
GO_0006915	Biological process	apoptotic process
GO_0001501	Biological process	skeletal system development
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0010804	Biological process	negative regulation of tumor necrosis factor-mediated signaling pathway
GO_0045671	Biological process	negative regulation of osteoclast differentiation
GO_0005615	Cellular component	extracellular space
GO_0043235	Cellular component	receptor complex
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0031012	Cellular component	extracellular matrix
GO_0038023	Molecular function	signaling receptor activity
GO_1904399	Molecular function	heparan sulfate binding
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

Gene name	TNFRSF11B
Protein name	TNF receptor superfamily member 11b Tumor necrosis factor receptor superfamily member 11B (Osteoclastogenesis inhibitory factor) (Osteoprotegerin)
Synonyms	OPG OCIF
Description	FUNCTION: Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. .
Accessions	O00300 ENST00000297350.9 ENST00000517352.1 E5RFV7

TNFRSF11B report