PRKCD report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRKCD at tissue level.

III. Associated gene sets

GO_2000753Biological processpositive regulation of glucosylceramide catabolic process
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0030837Biological processnegative regulation of actin filament polymerization
GO_2000755Biological processpositive regulation of sphingomyelin catabolic process
GO_0010469Biological processregulation of signaling receptor activity
GO_0043488Biological processregulation of mRNA stability
GO_0071447Biological processcellular response to hydroperoxide
GO_0034644Biological processcellular response to UV
GO_0007165Biological processsignal transduction
GO_0006974Biological processDNA damage response
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0023021Biological processtermination of signal transduction
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0043687Biological processpost-translational protein modification
GO_0090331Biological processnegative regulation of platelet aggregation
GO_0032147Biological processactivation of protein kinase activity
GO_0050732Biological processnegative regulation of peptidyl-tyrosine phosphorylation
GO_2000304Biological processpositive regulation of ceramide biosynthetic process
GO_2000303Biological processregulation of ceramide biosynthetic process
GO_0035556Biological processintracellular signal transduction
GO_0050728Biological processnegative regulation of inflammatory response
GO_0050821Biological processprotein stabilization
GO_0051490Biological processnegative regulation of filopodium assembly
GO_0016064Biological processimmunoglobulin mediated immune response
GO_0042742Biological processdefense response to bacterium
GO_0006915Biological processapoptotic process
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0032930Biological processpositive regulation of superoxide anion generation
GO_0090398Biological processcellular senescence
GO_0042100Biological processB cell proliferation
GO_0032079Biological processpositive regulation of endodeoxyribonuclease activity
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0034351Biological processnegative regulation of glial cell apoptotic process
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0008631Biological processintrinsic apoptotic signaling pathway in response to oxidative stress
GO_0032091Biological processnegative regulation of protein binding
GO_1900163Biological processpositive regulation of phospholipid scramblase activity
GO_0060326Biological processcell chemotaxis
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0042119Biological processneutrophil activation
GO_0035307Biological processpositive regulation of protein dephosphorylation
GO_1904385Biological processcellular response to angiotensin
GO_0035578Cellular componentazurophil granule lumen
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0036019Cellular componentendolysosome
GO_0005911Cellular componentcell-cell junction
GO_0016363Cellular componentnuclear matrix
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0008047Molecular functionenzyme activator activity
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004699Molecular functiondiacylglycerol-dependent, calcium-independent serine/threonine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0043560Molecular functioninsulin receptor substrate binding
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0004697Molecular functiondiacylglycerol-dependent serine/threonine kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKCD
Protein nameProtein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]
Protein kinase C delta
Protein kinase C gamma type
SynonymsPKCD
DescriptionFUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses . Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis . In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53 . In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53 . In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation (By similarity). Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1 . Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways . May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA . In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation . Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release . Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin . The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity). Phosphorylates ELAVL1 in response to angiotensin-2 treatment . Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis . Phosphorylates SMPD1 which induces SMPD1 secretion . .

AccessionsC9K0E3
ENST00000650940.1
ENST00000697588.1
ENST00000651505.1
ENST00000654719.1 [Q05655-1]
Q05655
ENST00000464818.1
A0A8V8TMH8
C9JZU8
ENST00000478843.5
A0A494C1T7
ENST00000487897.5
ENST00000477794.2
ENST00000330452.8 [Q05655-1]
ENST00000650739.1 [Q05655-1]
C9J9P1
ENST00000394729.6 [Q05655-1]
A0A494C125
A0A494BZX2
ENST00000652449.1 [Q05655-1]