THOC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006915Biological processapoptotic process
GO_0006406Biological processmRNA export from nucleus
GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0016363Cellular componentnuclear matrix
GO_0016607Cellular componentnuclear speck
GO_0000445Cellular componentTHO complex part of transcription export complex
GO_0005654Cellular componentnucleoplasm
GO_0000346Cellular componenttranscription export complex
GO_0000347Cellular componentTHO complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTHOC1
Protein nameTHO complex subunit 1
THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84)
SynonymsHPR1
DescriptionFUNCTION: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. May play a role in hair cell formation, hence may be involved in hearing (By similarity). .; FUNCTION: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.

AccessionsR4GN58
ENST00000261600.11 [Q96FV9-1]
ENST00000581116.1
J3QQZ3
J3KT14
ENST00000581269.5
ENST00000631280.2
ENST00000584642.1
ENST00000579891.5
J3KRD7
Q96FV9
ENST00000580038.5
R4GMN4