Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 27% ± 10% | |
oligodendrocyte | 9 studies | 30% ± 10% | |
astrocyte | 8 studies | 31% ± 12% | |
macrophage | 7 studies | 26% ± 5% | |
interneuron | 6 studies | 35% ± 21% | |
oligodendrocyte precursor cell | 6 studies | 30% ± 12% | |
GABAergic neuron | 6 studies | 39% ± 18% | |
microglial cell | 5 studies | 25% ± 6% | |
epithelial cell | 5 studies | 31% ± 12% | |
fibroblast | 5 studies | 21% ± 7% | |
endothelial cell of lymphatic vessel | 5 studies | 22% ± 5% | |
neuron | 4 studies | 28% ± 13% | |
adipocyte | 4 studies | 19% ± 4% | |
myeloid cell | 4 studies | 17% ± 2% | |
glutamatergic neuron | 4 studies | 56% ± 17% | |
smooth muscle cell | 4 studies | 17% ± 1% | |
granule cell | 3 studies | 19% ± 2% | |
lymphocyte | 3 studies | 21% ± 3% | |
dendritic cell | 3 studies | 19% ± 3% | |
monocyte | 3 studies | 16% ± 1% | |
transit amplifying cell | 3 studies | 34% ± 21% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1882.58 | 459 / 459 | 100% | 13.06 | 1118 / 1118 |
uterus | 100% | 2504.44 | 170 / 170 | 100% | 13.87 | 459 / 459 |
lung | 100% | 1639.21 | 578 / 578 | 100% | 9.82 | 1153 / 1155 |
prostate | 100% | 2503.07 | 245 / 245 | 100% | 8.80 | 501 / 502 |
brain | 100% | 1697.36 | 2635 / 2642 | 100% | 11.32 | 705 / 705 |
thymus | 100% | 2755.13 | 653 / 653 | 100% | 10.00 | 603 / 605 |
pancreas | 100% | 1155.05 | 328 / 328 | 99% | 8.49 | 177 / 178 |
esophagus | 100% | 1691.03 | 1444 / 1445 | 99% | 11.33 | 182 / 183 |
bladder | 100% | 1807.33 | 21 / 21 | 99% | 11.35 | 500 / 504 |
adrenal gland | 100% | 1530.86 | 258 / 258 | 98% | 6.53 | 226 / 230 |
ovary | 100% | 2392.92 | 180 / 180 | 98% | 7.05 | 422 / 430 |
stomach | 100% | 1362.52 | 359 / 359 | 98% | 7.18 | 279 / 286 |
intestine | 100% | 1859.95 | 966 / 966 | 98% | 7.38 | 514 / 527 |
skin | 100% | 1776.74 | 1809 / 1809 | 97% | 9.55 | 457 / 472 |
kidney | 100% | 1636.65 | 89 / 89 | 96% | 7.06 | 866 / 901 |
liver | 100% | 1088.50 | 226 / 226 | 95% | 5.73 | 386 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 13.41 | 29 / 29 |
spleen | 100% | 2424.95 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 11.09 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.26 | 1 / 1 |
adipose | 100% | 1700.42 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1417.62 | 1332 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 947.66 | 853 / 861 | 0% | 0 | 0 / 0 |
muscle | 99% | 759.85 | 792 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 71% | 4.22 | 57 / 80 |
peripheral blood | 61% | 707.07 | 566 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0006915 | Biological process | apoptotic process |
GO_0006406 | Biological process | mRNA export from nucleus |
GO_0008380 | Biological process | RNA splicing |
GO_0006397 | Biological process | mRNA processing |
GO_0016363 | Cellular component | nuclear matrix |
GO_0016607 | Cellular component | nuclear speck |
GO_0000445 | Cellular component | THO complex part of transcription export complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000346 | Cellular component | transcription export complex |
GO_0000347 | Cellular component | THO complex |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | THOC1 |
Protein name | THO complex subunit 1 THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84) |
Synonyms | HPR1 |
Description | FUNCTION: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. May play a role in hair cell formation, hence may be involved in hearing (By similarity). .; FUNCTION: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1. |
Accessions | R4GN58 ENST00000261600.11 [Q96FV9-1] ENST00000581116.1 J3QQZ3 J3KT14 ENST00000581269.5 ENST00000631280.2 ENST00000584642.1 ENST00000579891.5 J3KRD7 Q96FV9 ENST00000580038.5 R4GMN4 |