XBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990418Biological processresponse to insulin-like growth factor stimulus
GO_0055092Biological processsterol homeostasis
GO_0006366Biological processtranscription by RNA polymerase II
GO_0001525Biological processangiogenesis
GO_0071333Biological processcellular response to glucose stimulus
GO_0042149Biological processcellular response to glucose starvation
GO_2000347Biological processpositive regulation of hepatocyte proliferation
GO_0045348Biological processpositive regulation of MHC class II biosynthetic process
GO_0002639Biological processpositive regulation of immunoglobulin production
GO_0032869Biological processcellular response to insulin stimulus
GO_0055089Biological processfatty acid homeostasis
GO_1902236Biological processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0045766Biological processpositive regulation of angiogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0036500Biological processATF6-mediated unfolded protein response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0031670Biological processcellular response to nutrient
GO_0001889Biological processliver development
GO_0071353Biological processcellular response to interleukin-4
GO_0045579Biological processpositive regulation of B cell differentiation
GO_0042632Biological processcholesterol homeostasis
GO_0035470Biological processpositive regulation of vascular wound healing
GO_0006955Biological processimmune response
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0010832Biological processnegative regulation of myotube differentiation
GO_0006633Biological processfatty acid biosynthetic process
GO_1900103Biological processpositive regulation of endoplasmic reticulum unfolded protein response
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_0036498Biological processIRE1-mediated unfolded protein response
GO_0048666Biological processneuron development
GO_0071375Biological processcellular response to peptide hormone stimulus
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0007517Biological processmuscle organ development
GO_0071230Biological processcellular response to amino acid stimulus
GO_0060612Biological processadipose tissue development
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0006915Biological processapoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0015031Biological processprotein transport
GO_0006914Biological processautophagy
GO_1900100Biological processpositive regulation of plasma cell differentiation
GO_1903489Biological processpositive regulation of lactation
GO_0071332Biological processcellular response to fructose stimulus
GO_0036503Biological processERAD pathway
GO_0035356Biological processintracellular triglyceride homeostasis
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameXBP1
Protein nameX-box-binding protein 1
X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]
SynonymsXBP2
TREB5
DescriptionFUNCTION: Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins . Modulates the cellular response to ER stress in a PIK3R-dependent manner . Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes . Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity). .; FUNCTION: [Isoform 1]: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient IRE1-mediated XBP1 mRNA isoform 2 production . In endothelial cells (EC), associated with KDR, promotes IRE1-mediated XBP1 mRNA isoform 2 productions in a vascular endothelial growth factor (VEGF)-dependent manner, leading to EC proliferation and angiogenesis . Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus preventing the constitutive activation of the ER stress response signaling pathway . Inhibits the transactivation activity of XBP1 isoform 2 in myeloma cells (By similarity). Acts as a weak transcriptional factor . Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress . Binds to the ER stress response element (ERSE) upon ER stress . Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences . Binds the Tax-responsive element (TRE) present in the long terminal repeat (LTR) of T-cell leukemia virus type 1 (HTLV-I) and to the TPA response elements (TRE) . Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner . Binds to the CDH5/VE-cadherin gene promoter region . .; FUNCTION: [Isoform 2]: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress . Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion . Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression . Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions . Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation . Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells . Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation. Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells. Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance. Improves also glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels. Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity). Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner . Binds to the BECN1 gene promoter region . Binds to the CDH5/VE-cadherin gene promoter region . Binds to the ER stress response element (ERSE) upon ER stress . Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity). .

AccessionsENST00000405219.7
B1AHH1
ENST00000344347.6 [P17861-2]
B1AHH2
ENST00000403532.7
ENST00000216037.10 [P17861-1]
P17861