THOC6 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	4 studies	36% ± 17%	Explore
basal cell	4 studies	21% ± 7%	Explore
conventional dendritic cell	3 studies	29% ± 9%	Explore
hematopoietic precursor cell	3 studies	22% ± 3%	Explore
dendritic cell	3 studies	32% ± 3%	Explore
plasmacytoid dendritic cell	3 studies	24% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of THOC6 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1016.44	1445 / 1445	100%	35.27	183 / 183
ovary	100%	761.52	180 / 180	100%	43.21	430 / 430
skin	100%	1242.39	1809 / 1809	100%	49.85	472 / 472
thymus	100%	1151.35	653 / 653	100%	47.52	605 / 605
uterus	100%	1317.76	170 / 170	100%	76.61	459 / 459
breast	100%	1070.78	459 / 459	99%	55.42	1112 / 1118
pancreas	100%	498.62	328 / 328	99%	44.33	177 / 178
intestine	100%	1143.85	966 / 966	99%	55.58	524 / 527
kidney	100%	1052.24	89 / 89	99%	44.62	895 / 901
lung	100%	1228.81	578 / 578	99%	48.95	1146 / 1155
prostate	100%	1496.57	245 / 245	99%	44.09	498 / 502
adrenal gland	100%	1022.96	258 / 258	99%	40.14	228 / 230
bladder	100%	1153.52	21 / 21	99%	58.12	499 / 504
liver	100%	716.12	226 / 226	99%	29.77	401 / 406
stomach	100%	820.71	359 / 359	99%	45.75	282 / 286
brain	96%	395.80	2525 / 2642	99%	28.20	695 / 705
adipose	100%	985.44	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	45.97	80 / 80
lymph node	0%	0	0 / 0	100%	80.24	29 / 29
spleen	100%	1504.58	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	64.61	45 / 45
ureter	0%	0	0 / 0	100%	67.76	1 / 1
muscle	100%	919.66	801 / 803	0%	0	0 / 0
blood vessel	100%	1019.89	1331 / 1335	0%	0	0 / 0
heart	99%	595.56	849 / 861	0%	0	0 / 0
peripheral blood	97%	799.48	903 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006406	Biological process	mRNA export from nucleus
GO_0006915	Biological process	apoptotic process
GO_0008380	Biological process	RNA splicing
GO_0006397	Biological process	mRNA processing
GO_0007417	Biological process	central nervous system development
GO_0016607	Cellular component	nuclear speck
GO_0000445	Cellular component	THO complex part of transcription export complex
GO_0005654	Cellular component	nucleoplasm
GO_0000346	Cellular component	transcription export complex
GO_0000347	Cellular component	THO complex
GO_0000781	Cellular component	chromosome, telomeric region
GO_0016604	Cellular component	nuclear body
GO_0005634	Cellular component	nucleus
GO_0003723	Molecular function	RNA binding

Gene name	THOC6
Protein name	THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)
Synonyms	WDR58 PSEC0006
Description	FUNCTION: Acts as a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development. .
Accessions	ENST00000574549.5 [Q86W42-2] Q86W42 ENST00000253952.9 [Q86W42-3] ENST00000575576.5 [Q86W42-2] ENST00000326266.13 [Q86W42-1]

THOC6 report