UNC5D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0038007Biological processnetrin-activated signaling pathway
GO_0098742Biological processcell-cell adhesion via plasma-membrane adhesion molecules
GO_0021859Biological processpyramidal neuron differentiation
GO_2001222Biological processregulation of neuron migration
GO_0007411Biological processaxon guidance
GO_0009986Cellular componentcell surface
GO_0005886Cellular componentplasma membrane
GO_0005042Molecular functionnetrin receptor activity

IV. Literature review

[source]
Gene nameUNC5D
Protein nameNetrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D)
Netrin receptor UNC5
Unc-5 netrin receptor D
SynonymsKIAA1777
UNQ6012/PRO34692
UNC5H4
DescriptionFUNCTION: Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage . It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand . Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity). .

FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. .

FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. .

FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. .

AccessionsENST00000416672.5
C9J1I0
ENST00000404895.7 [Q6UXZ4-1]
ENST00000287272.6
Q6UXZ4
ENST00000420357.5
ENST00000453357.6 [Q6UXZ4-2]
C9J2B6
E9PDS8
ENST00000449677.1
H7BXJ2