PSMD10 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PSMD10 at tissue level.

III. Associated gene sets

GO_0072659Biological processprotein localization to plasma membrane
GO_0030307Biological processpositive regulation of cell growth
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0090201Biological processnegative regulation of release of cytochrome c from mitochondria
GO_0045737Biological processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0007253Biological processcytoplasmic sequestering of NF-kappaB
GO_0043066Biological processnegative regulation of apoptotic process
GO_0043409Biological processnegative regulation of MAPK cascade
GO_0006915Biological processapoptotic process
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0070682Biological processproteasome regulatory particle assembly
GO_0043518Biological processnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO_0000502Cellular componentproteasome complex
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0043005Cellular componentneuron projection
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0005829Cellular componentcytosol
GO_0008540Cellular componentproteasome regulatory particle, base subcomplex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0044325Molecular functiontransmembrane transporter binding
GO_0008092Molecular functioncytoskeletal protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePSMD10
Protein name26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))
Proteasome 26S subunit, non-ATPase 10
Synonyms
DescriptionFUNCTION: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.; FUNCTION: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.

AccessionsENST00000217958.8 [O75832-1]
ENST00000340200.5
B1AJY5
B1AJY6
ENST00000372295.5
O75832
ENST00000372296.5
ENST00000361815.9 [O75832-2]
B1AJY7