CARD14 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CARD14 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CARD14 at tissue level.

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0007250Biological processactivation of NF-kappaB-inducing kinase activity
GO_0043066Biological processnegative regulation of apoptotic process
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0016235Cellular componentaggresome
GO_0005737Cellular componentcytoplasm
GO_0050700Molecular functionCARD domain binding

IV. Literature review

[source]
Gene nameCARD14
Protein nameCaspase recruitment domain family member 14
Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2)
Caspase recruitment domain family member 14 (Caspase recruitment domain family, member 14, isoform CRA_d)
SynonymsCARMA2
hCG_28572
DescriptionFUNCTION: Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases . May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. .; FUNCTION: [Isoform 3]: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator . .

AccessionsENST00000651068.1
A0A3B3ITQ9
ENST00000703567.1
ENST00000651388.1
ENST00000571450.1
I3L3F1
I3L414
ENST00000651672.1
ENST00000650867.1
A0A494C199
ENST00000344227.6 [Q9BXL6-1]
ENST00000570421.5 [Q9BXL6-2]
ENST00000703568.1
A0A494C1N2
ENST00000575465.6
A0A994J6G4
ENST00000703566.1
I3L1Z7
ENST00000571427.2 [Q9BXL6-1]
ENST00000573882.5 [Q9BXL6-1]
Q9BXL6
ENST00000648128.1
A0A494BZY0
ENST00000648509.2 [Q9BXL6-1]
A0A494C0J4
ENST00000575500.5