CASP6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030855Biological processepithelial cell differentiation
GO_0060545Biological processpositive regulation of necroptotic process
GO_0016540Biological processprotein autoprocessing
GO_0043067Biological processregulation of programmed cell death
GO_0070269Biological processpyroptotic inflammatory response
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0072734Biological processcellular response to staurosporine
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0097284Biological processhepatocyte apoptotic process
GO_0006508Biological processproteolysis
GO_0002218Biological processactivation of innate immune response
GO_0097194Biological processexecution phase of apoptosis
GO_0006915Biological processapoptotic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0097153Molecular functioncysteine-type endopeptidase activity involved in apoptotic process
GO_0042802Molecular functionidentical protein binding
GO_0097200Molecular functioncysteine-type endopeptidase activity involved in execution phase of apoptosis
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCASP6
Protein nameCaspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]
Caspase 6
SynonymsMCH2
DescriptionFUNCTION: Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity . Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation . Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution . Acts as a regulator of liver damage by promoting hepatocyte apoptosis: in absence of phosphorylation by AMP-activated protein kinase (AMPK), catalyzes cleavage of BID, leading to cytochrome c release, thereby participating in nonalcoholic steatohepatitis . Cleaves PARK7/DJ-1 in cells undergoing apoptosis (By similarity). Involved in intrinsic apoptosis by mediating cleavage of RIPK1 . Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP . Cleaves phospholipid scramblase proteins XKR4 and XKR9 (By similarity). In addition to apoptosis, involved in different forms of programmed cell death . Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity . PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis . Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death . Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis (By similarity). Regulates B-cell programs both during early development and after antigen stimulation (By similarity). .; FUNCTION: (Microbial infection) Proteolytically cleaves the N protein of coronoviruses such as MERS-CoV and SARS-CoV . The cleavage of MERS-CoV N-protein leads to two fragments and modulates coronavirus replication by regulating IFN signaling. The two fragments produced by the cleavage interact with IRF3 inhibiting its nuclear translocation after activation and reduce the expression of IFNB and IFN-stimulated genes . The same mechanism seems to be used by other coronaviruses such as SARS-CoV and SARS-CoV-2 to enhance their replication . .

AccessionsENST00000503684.5
D6RBM3
D6RHU3
ENST00000265164.7 [P55212-1]
ENST00000352981.7 [P55212-2]
ENST00000505486.1
P55212