BBC3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BBC3 at tissue level.

III. Associated gene sets

GO_0090200Biological processpositive regulation of release of cytochrome c from mitochondria
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0008340Biological processdetermination of adult lifespan
GO_0070245Biological processpositive regulation of thymocyte apoptotic process
GO_1903896Biological processpositive regulation of IRE1-mediated unfolded protein response
GO_0006974Biological processDNA damage response
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0070231Biological processT cell apoptotic process
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_2000271Biological processpositive regulation of fibroblast apoptotic process
GO_1902237Biological processpositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_2001056Biological processpositive regulation of cysteine-type endopeptidase activity
GO_0001836Biological processrelease of cytochrome c from mitochondria
GO_0097194Biological processexecution phase of apoptosis
GO_0006915Biological processapoptotic process
GO_0071479Biological processcellular response to ionizing radiation
GO_0044346Biological processfibroblast apoptotic process
GO_0045926Biological processnegative regulation of growth
GO_1903749Biological processpositive regulation of establishment of protein localization to mitochondrion
GO_0071456Biological processcellular response to hypoxia
GO_0005739Cellular componentmitochondrion
GO_0005764Cellular componentlysosome
GO_0005829Cellular componentcytosol
GO_0005741Cellular componentmitochondrial outer membrane
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBBC3
Protein nameBcl-2-binding component 3, isoforms 3/4 (JFY-1) (p53 up-regulated modulator of apoptosis)
Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis)
SynonymsPUMA
DescriptionFUNCTION: [Isoform 3]: Does not affect cell growth. .

FUNCTION: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis . Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis . Regulates ER stress-induced neuronal apoptosis (By similarity). .

AccessionsQ96PG8
ENST00000439096.3 [Q9BXH1-1]
ENST00000341983.8 [Q9BXH1-2]
Q9BXH1
ENST00000449228.5 [Q96PG8-2]
ENST00000300880.11 [Q96PG8-1]