RTN3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	37 studies	28% ± 12%	Explore
endothelial cell	28 studies	29% ± 16%	Explore
fibroblast	26 studies	24% ± 10%	Explore
classical monocyte	26 studies	37% ± 16%	Explore
monocyte	19 studies	33% ± 13%	Explore
non-classical monocyte	19 studies	32% ± 12%	Explore
astrocyte	19 studies	42% ± 13%	Explore
smooth muscle cell	18 studies	23% ± 6%	Explore
epithelial cell	18 studies	33% ± 17%	Explore
ciliated cell	17 studies	33% ± 14%	Explore
pericyte	17 studies	26% ± 10%	Explore
mast cell	16 studies	20% ± 4%	Explore
oligodendrocyte	16 studies	53% ± 15%	Explore
oligodendrocyte precursor cell	16 studies	49% ± 19%	Explore
basal cell	13 studies	27% ± 13%	Explore
connective tissue cell	13 studies	25% ± 10%	Explore
microglial cell	13 studies	32% ± 10%	Explore
type I pneumocyte	12 studies	29% ± 9%	Explore
glutamatergic neuron	12 studies	78% ± 20%	Explore
myeloid cell	12 studies	34% ± 16%	Explore
natural killer cell	11 studies	21% ± 7%	Explore
endothelial cell of lymphatic vessel	11 studies	25% ± 6%	Explore
GABAergic neuron	11 studies	71% ± 20%	Explore
neuron	11 studies	64% ± 21%	Explore
myofibroblast cell	11 studies	22% ± 6%	Explore
neutrophil	10 studies	33% ± 13%	Explore
mesothelial cell	10 studies	37% ± 18%	Explore
plasma cell	9 studies	28% ± 11%	Explore
platelet	9 studies	33% ± 10%	Explore
adipocyte	9 studies	59% ± 15%	Explore
alveolar macrophage	8 studies	40% ± 8%	Explore
conventional dendritic cell	8 studies	34% ± 12%	Explore
capillary endothelial cell	8 studies	19% ± 4%	Explore
progenitor cell	8 studies	32% ± 12%	Explore
amacrine cell	8 studies	49% ± 19%	Explore
retinal ganglion cell	8 studies	79% ± 26%	Explore
retinal cone cell	8 studies	48% ± 18%	Explore
retinal rod cell	8 studies	32% ± 8%	Explore
plasmacytoid dendritic cell	8 studies	24% ± 9%	Explore
dendritic cell	8 studies	27% ± 13%	Explore
mononuclear phagocyte	7 studies	25% ± 10%	Explore
CD4-positive, alpha-beta T cell	7 studies	19% ± 4%	Explore
interneuron	7 studies	76% ± 19%	Explore
abnormal cell	7 studies	38% ± 15%	Explore
type II pneumocyte	7 studies	24% ± 10%	Explore
endothelial cell of vascular tree	7 studies	19% ± 2%	Explore
regulatory T cell	7 studies	18% ± 2%	Explore
hematopoietic precursor cell	6 studies	43% ± 15%	Explore
T cell	6 studies	25% ± 9%	Explore
hematopoietic stem cell	6 studies	40% ± 11%	Explore
club cell	6 studies	23% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	18% ± 2%	Explore
retina horizontal cell	6 studies	42% ± 14%	Explore
secretory cell	5 studies	28% ± 7%	Explore
vein endothelial cell	5 studies	17% ± 1%	Explore
retinal bipolar neuron	5 studies	44% ± 16%	Explore
OFF-bipolar cell	5 studies	54% ± 24%	Explore
ON-bipolar cell	5 studies	54% ± 24%	Explore
pro-B cell	5 studies	32% ± 9%	Explore
Mueller cell	5 studies	37% ± 14%	Explore
CD8-positive, alpha-beta T cell	5 studies	20% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	18% ± 2%	Explore
plasmablast	4 studies	49% ± 23%	Explore
duct epithelial cell	4 studies	28% ± 3%	Explore
respiratory goblet cell	4 studies	32% ± 13%	Explore
pancreatic A cell	4 studies	47% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	46% ± 1%	Explore
leukocyte	4 studies	24% ± 5%	Explore
granule cell	4 studies	58% ± 11%	Explore
GABAergic amacrine cell	4 studies	65% ± 10%	Explore
glycinergic amacrine cell	4 studies	47% ± 8%	Explore
lymphocyte	4 studies	22% ± 7%	Explore
megakaryocyte	4 studies	43% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	17% ± 1%	Explore
adventitial cell	4 studies	26% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 5%	Explore
gamma-delta T cell	4 studies	26% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	28% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	61% ± 28%	Explore
enteroendocrine cell	4 studies	31% ± 17%	Explore
transit amplifying cell	4 studies	25% ± 12%	Explore
ionocyte	3 studies	31% ± 6%	Explore
squamous epithelial cell	3 studies	38% ± 27%	Explore
type B pancreatic cell	3 studies	56% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
glomerular endothelial cell	3 studies	17% ± 1%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	42% ± 19%	Explore
neural crest cell	3 studies	34% ± 12%	Explore
GABAergic interneuron	3 studies	73% ± 10%	Explore
glial cell	3 studies	40% ± 15%	Explore
kidney loop of Henle epithelial cell	3 studies	28% ± 8%	Explore
retinal pigment epithelial cell	3 studies	39% ± 17%	Explore
mucus secreting cell	3 studies	25% ± 0%	Explore
serous secreting cell	3 studies	33% ± 12%	Explore
rod bipolar cell	3 studies	59% ± 8%	Explore
acinar cell	3 studies	38% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
intermediate monocyte	3 studies	45% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
innate lymphoid cell	3 studies	19% ± 1%	Explore
pancreatic ductal cell	3 studies	57% ± 22%	Explore
ependymal cell	3 studies	47% ± 19%	Explore
goblet cell	3 studies	29% ± 14%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 9%	Explore
keratinocyte	3 studies	22% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	21% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	20 studies	56% ± 21%	Explore
lung	17 studies	25% ± 7%	Explore
peripheral blood	13 studies	22% ± 6%	Explore
eye	11 studies	37% ± 14%	Explore
kidney	7 studies	22% ± 5%	Explore
intestine	7 studies	22% ± 9%	Explore
bone marrow	5 studies	23% ± 8%	Explore
uterus	4 studies	29% ± 15%	Explore
breast	4 studies	20% ± 2%	Explore
adipose	4 studies	30% ± 12%	Explore
pancreas	3 studies	55% ± 10%	Explore
heart	3 studies	16% ± 0%	Explore
liver	3 studies	37% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	41437.18	2640 / 2642	100%	423.47	705 / 705
thymus	100%	10689.51	650 / 653	100%	148.47	603 / 605
breast	100%	11544.86	457 / 459	99%	164.92	1111 / 1118
uterus	99%	7237.28	168 / 170	100%	104.89	458 / 459
bladder	100%	6287.05	21 / 21	98%	95.92	495 / 504
lung	98%	7918.29	568 / 578	100%	96.83	1154 / 1155
intestine	99%	7704.45	953 / 966	99%	94.93	522 / 527
skin	100%	11465.96	1803 / 1809	98%	76.37	462 / 472
esophagus	97%	6327.76	1396 / 1445	100%	81.50	183 / 183
pancreas	94%	5704.27	307 / 328	100%	97.10	178 / 178
ovary	91%	4893.97	163 / 180	100%	133.89	430 / 430
stomach	85%	5064.21	306 / 359	100%	88.12	286 / 286
adrenal gland	88%	6666.69	226 / 258	96%	132.67	221 / 230
kidney	83%	5196.75	74 / 89	99%	91.59	891 / 901
prostate	80%	4161.22	197 / 245	99%	89.81	498 / 502
liver	54%	2847.56	121 / 226	99%	71.73	403 / 406
adipose	100%	13913.32	1204 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	82.55	45 / 45
ureter	0%	0	0 / 0	100%	57.29	1 / 1
blood vessel	99%	7949.29	1320 / 1335	0%	0	0 / 0
peripheral blood	98%	24500.65	907 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	47.73	28 / 29
eye	0%	0	0 / 0	96%	52.47	77 / 80
spleen	88%	5773.26	213 / 241	0%	0	0 / 0
muscle	78%	4676.59	625 / 803	0%	0	0 / 0
heart	58%	3046.21	499 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007420	Biological process	brain development
GO_0006915	Biological process	apoptotic process
GO_0071786	Biological process	endoplasmic reticulum tubular network organization
GO_0071787	Biological process	endoplasmic reticulum tubular network formation
GO_0030182	Biological process	neuron differentiation
GO_0016192	Biological process	vesicle-mediated transport
GO_1902430	Biological process	negative regulation of amyloid-beta formation
GO_0005615	Cellular component	extracellular space
GO_0000139	Cellular component	Golgi membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005794	Cellular component	Golgi apparatus
GO_0005886	Cellular component	plasma membrane
GO_0014069	Cellular component	postsynaptic density
GO_0043005	Cellular component	neuron projection
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RTN3
Protein name	Truncated RTN3-A3 Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII) Reticulon 3 Reticulon
Synonyms	ASYIP hCG_1775344 NSPL2
Description	FUNCTION: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules . Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. .; FUNCTION: (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. .
Accessions	ENST00000540798.5 [O95197-7] F5H617 ENST00000543552.5 ENST00000339997.8 [O95197-2] B7Z4M1 ENST00000341307.6 [O95197-5] O95197 ENST00000377819.10 [O95197-1] Q7RTN4 ENST00000536011.5 ENST00000356000.7 [O95197-4] ENST00000542238.5 ENST00000354497.4 [O95197-6] ENST00000537981.5 [O95197-3] F5GWG7 ENST00000545432.5 F5H891

RTN3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review