SGK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0070294Biological processrenal sodium ion absorption
GO_0001558Biological processregulation of cell growth
GO_0007616Biological processlong-term memory
GO_0008217Biological processregulation of blood pressure
GO_0006974Biological processDNA damage response
GO_0060453Biological processregulation of gastric acid secretion
GO_0048812Biological processneuron projection morphogenesis
GO_0035556Biological processintracellular signal transduction
GO_0042981Biological processregulation of apoptotic process
GO_1904045Biological processcellular response to aldosterone
GO_0006814Biological processsodium ion transport
GO_0030334Biological processregulation of cell migration
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0050790Biological processregulation of catalytic activity
GO_0006915Biological processapoptotic process
GO_0032411Biological processpositive regulation of transporter activity
GO_0051090Biological processregulation of DNA-binding transcription factor activity
GO_0006468Biological processprotein phosphorylation
GO_0042127Biological processregulation of cell population proliferation
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005246Molecular functioncalcium channel regulator activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0017081Molecular functionchloride channel regulator activity
GO_0015459Molecular functionpotassium channel regulator activity
GO_0005524Molecular functionATP binding
GO_0017080Molecular functionsodium channel regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSGK1
Protein nameSerum/glucocorticoid regulated kinase 1
Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1)
Sgk1 variant i3
SynonymsSGK
DKFZp686H1615
DescriptionFUNCTION: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1. .

AccessionsENST00000461976.2
Q7Z3I4
ENST00000460769.1
H0YCJ3
E9PJN2
ENST00000528577.5 [O00141-5]
ENST00000367858.10 [O00141-2]
ENST00000475719.6
ENST00000413996.7 [O00141-3]
O00141
E9PR89
ENST00000367857.9 [O00141-4]
ENST00000237305.12 [O00141-1]
ENST00000524929.1
E9PP33
ENST00000533224.1
R4I3I2