Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 39 studies | 44% ± 17% | |
endothelial cell | 39 studies | 36% ± 12% | |
conventional dendritic cell | 28 studies | 47% ± 17% | |
mast cell | 27 studies | 40% ± 16% | |
classical monocyte | 25 studies | 34% ± 12% | |
monocyte | 19 studies | 37% ± 17% | |
dendritic cell | 18 studies | 41% ± 19% | |
microglial cell | 17 studies | 41% ± 18% | |
basal cell | 16 studies | 29% ± 11% | |
non-classical monocyte | 16 studies | 29% ± 11% | |
oligodendrocyte | 16 studies | 61% ± 19% | |
oligodendrocyte precursor cell | 15 studies | 56% ± 20% | |
capillary endothelial cell | 14 studies | 44% ± 15% | |
GABAergic neuron | 11 studies | 42% ± 17% | |
myeloid cell | 11 studies | 46% ± 18% | |
endothelial cell of artery | 10 studies | 27% ± 9% | |
endothelial cell of vascular tree | 10 studies | 31% ± 13% | |
glutamatergic neuron | 9 studies | 39% ± 21% | |
alveolar macrophage | 8 studies | 27% ± 7% | |
epithelial cell | 8 studies | 47% ± 18% | |
mesothelial cell | 8 studies | 40% ± 21% | |
vein endothelial cell | 8 studies | 23% ± 5% | |
secretory cell | 7 studies | 35% ± 14% | |
ciliated cell | 7 studies | 25% ± 15% | |
fibroblast | 7 studies | 21% ± 7% | |
leukocyte | 7 studies | 34% ± 8% | |
club cell | 6 studies | 35% ± 7% | |
mononuclear phagocyte | 6 studies | 46% ± 18% | |
astrocyte | 6 studies | 38% ± 14% | |
enterocyte | 6 studies | 38% ± 14% | |
interneuron | 6 studies | 45% ± 20% | |
neutrophil | 6 studies | 24% ± 7% | |
respiratory goblet cell | 5 studies | 45% ± 6% | |
CD4-positive, alpha-beta T cell | 5 studies | 20% ± 4% | |
retinal pigment epithelial cell | 5 studies | 55% ± 22% | |
endothelial cell of lymphatic vessel | 4 studies | 18% ± 1% | |
monocyte-derived dendritic cell | 4 studies | 58% ± 18% | |
glomerular endothelial cell | 4 studies | 78% ± 5% | |
neuron | 4 studies | 35% ± 17% | |
granule cell | 4 studies | 37% ± 9% | |
retinal ganglion cell | 4 studies | 42% ± 20% | |
inflammatory macrophage | 4 studies | 41% ± 23% | |
endothelial cell of sinusoid | 4 studies | 36% ± 11% | |
intermediate monocyte | 4 studies | 44% ± 9% | |
keratinocyte | 4 studies | 22% ± 6% | |
hillock cell | 3 studies | 27% ± 6% | |
plasmablast | 3 studies | 27% ± 10% | |
podocyte | 3 studies | 32% ± 10% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 56% ± 14% | |
GABAergic interneuron | 3 studies | 37% ± 3% | |
abnormal cell | 3 studies | 22% ± 5% | |
CD8-positive, alpha-beta T cell | 3 studies | 22% ± 6% | |
granulocyte | 3 studies | 27% ± 9% | |
T follicular helper cell | 3 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
skin | 99% | 10592.13 | 1797 / 1809 | 100% | 105.41 | 470 / 472 |
pancreas | 100% | 8957.15 | 327 / 328 | 94% | 33.05 | 167 / 178 |
lung | 98% | 15239.57 | 567 / 578 | 94% | 69.93 | 1084 / 1155 |
kidney | 100% | 9425.44 | 89 / 89 | 92% | 56.95 | 826 / 901 |
brain | 83% | 3787.54 | 2193 / 2642 | 97% | 54.93 | 687 / 705 |
thymus | 99% | 10083.10 | 648 / 653 | 80% | 25.77 | 483 / 605 |
breast | 99% | 8026.42 | 453 / 459 | 79% | 19.92 | 886 / 1118 |
ovary | 100% | 24603.82 | 180 / 180 | 77% | 19.73 | 330 / 430 |
esophagus | 73% | 4789.50 | 1048 / 1445 | 94% | 82.02 | 172 / 183 |
adrenal gland | 100% | 17172.48 | 258 / 258 | 63% | 21.45 | 145 / 230 |
stomach | 93% | 11075.21 | 333 / 359 | 68% | 20.26 | 195 / 286 |
uterus | 71% | 3298.86 | 120 / 170 | 84% | 48.87 | 384 / 459 |
prostate | 86% | 9947.98 | 211 / 245 | 68% | 33.04 | 341 / 502 |
liver | 79% | 6799.54 | 178 / 226 | 58% | 15.75 | 236 / 406 |
bladder | 67% | 2148.81 | 14 / 21 | 67% | 27.37 | 337 / 504 |
intestine | 66% | 9045.56 | 641 / 966 | 60% | 15.25 | 318 / 527 |
adipose | 99% | 13915.40 | 1191 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 122.56 | 44 / 45 |
spleen | 93% | 3742.56 | 225 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 37.59 | 26 / 29 |
heart | 80% | 3654.06 | 692 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 60% | 2958.79 | 798 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 48% | 18.34 | 38 / 80 |
muscle | 42% | 1286.28 | 341 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 33% | 1157.20 | 307 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0070294 | Biological process | renal sodium ion absorption |
GO_0001558 | Biological process | regulation of cell growth |
GO_0007616 | Biological process | long-term memory |
GO_0008217 | Biological process | regulation of blood pressure |
GO_0006974 | Biological process | DNA damage response |
GO_0060453 | Biological process | regulation of gastric acid secretion |
GO_0048812 | Biological process | neuron projection morphogenesis |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_1904045 | Biological process | cellular response to aldosterone |
GO_0006814 | Biological process | sodium ion transport |
GO_0030334 | Biological process | regulation of cell migration |
GO_1901796 | Biological process | regulation of signal transduction by p53 class mediator |
GO_0050790 | Biological process | regulation of catalytic activity |
GO_0006915 | Biological process | apoptotic process |
GO_0032411 | Biological process | positive regulation of transporter activity |
GO_0051090 | Biological process | regulation of DNA-binding transcription factor activity |
GO_0006468 | Biological process | protein phosphorylation |
GO_0042127 | Biological process | regulation of cell population proliferation |
GO_0005886 | Cellular component | plasma membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0004712 | Molecular function | protein serine/threonine/tyrosine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005246 | Molecular function | calcium channel regulator activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0017081 | Molecular function | chloride channel regulator activity |
GO_0015459 | Molecular function | potassium channel regulator activity |
GO_0005524 | Molecular function | ATP binding |
GO_0017080 | Molecular function | sodium channel regulator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | SGK1 |
Protein name | Serum/glucocorticoid regulated kinase 1 Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) Sgk1 variant i3 |
Synonyms | SGK DKFZp686H1615 |
Description | FUNCTION: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na(+) transport than isoform 1. . |
Accessions | ENST00000461976.2 Q7Z3I4 ENST00000460769.1 H0YCJ3 E9PJN2 ENST00000528577.5 [O00141-5] ENST00000367858.10 [O00141-2] ENST00000475719.6 ENST00000413996.7 [O00141-3] O00141 E9PR89 ENST00000367857.9 [O00141-4] ENST00000237305.12 [O00141-1] ENST00000524929.1 E9PP33 ENST00000533224.1 R4I3I2 |