RNF152 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0016567Biological processprotein ubiquitination
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0006513Biological processprotein monoubiquitination
GO_0010508Biological processpositive regulation of autophagy
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0034198Biological processcellular response to amino acid starvation
GO_0005764Cellular componentlysosome
GO_0031090Cellular componentorganelle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF152
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27)
E3 ubiquitin-protein ligase RNF152 (EC 2.3.2.27) (RING finger protein 152) (RING-type E3 ubiquitin transferase RNF152)
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB . Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling . Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition . Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation . Induces apoptosis when overexpressed . .

AccessionsENST00000591306.5
ENST00000312828.4
K7EMG3
Q8N8N0