Name | Number of supported studies | Average coverage | |
---|---|---|---|
pericyte | 23 studies | 37% ± 17% | |
smooth muscle cell | 14 studies | 28% ± 11% | |
endothelial cell | 9 studies | 28% ± 11% | |
ionocyte | 5 studies | 36% ± 19% | |
glutamatergic neuron | 5 studies | 31% ± 21% | |
epithelial cell of proximal tubule | 5 studies | 41% ± 17% | |
epithelial cell | 5 studies | 36% ± 16% | |
endothelial cell of lymphatic vessel | 5 studies | 32% ± 10% | |
interneuron | 4 studies | 23% ± 5% | |
GABAergic neuron | 4 studies | 31% ± 17% | |
granule cell | 3 studies | 28% ± 8% | |
neuron | 3 studies | 25% ± 6% | |
rod bipolar cell | 3 studies | 34% ± 8% | |
hepatocyte | 3 studies | 70% ± 22% | |
oligodendrocyte | 3 studies | 21% ± 3% | |
renal alpha-intercalated cell | 3 studies | 57% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 99% | 3024.67 | 455 / 459 | 97% | 15.08 | 1086 / 1118 |
liver | 100% | 4470.58 | 226 / 226 | 92% | 7.99 | 374 / 406 |
kidney | 100% | 7315.10 | 89 / 89 | 89% | 28.49 | 798 / 901 |
uterus | 100% | 3238.43 | 170 / 170 | 83% | 9.69 | 380 / 459 |
prostate | 98% | 2488.84 | 239 / 245 | 83% | 4.52 | 415 / 502 |
lung | 99% | 2980.56 | 575 / 578 | 76% | 6.81 | 876 / 1155 |
esophagus | 76% | 1063.73 | 1100 / 1445 | 90% | 10.48 | 165 / 183 |
ovary | 76% | 1523.33 | 136 / 180 | 87% | 7.95 | 372 / 430 |
bladder | 95% | 1599.90 | 20 / 21 | 65% | 4.66 | 330 / 504 |
adrenal gland | 80% | 961.42 | 207 / 258 | 78% | 6.51 | 180 / 230 |
thymus | 99% | 2503.58 | 645 / 653 | 57% | 2.44 | 345 / 605 |
stomach | 98% | 2052.20 | 353 / 359 | 53% | 2.61 | 152 / 286 |
intestine | 88% | 1810.06 | 854 / 966 | 46% | 2.19 | 243 / 527 |
brain | 60% | 1546.37 | 1585 / 2642 | 71% | 2.63 | 500 / 705 |
pancreas | 28% | 214.25 | 91 / 328 | 92% | 5.09 | 164 / 178 |
skin | 77% | 3551.30 | 1398 / 1809 | 27% | 1.66 | 128 / 472 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.42 | 1 / 1 |
blood vessel | 100% | 5200.82 | 1332 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 3052.90 | 1189 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 11.80 | 43 / 45 |
heart | 92% | 1775.67 | 794 / 861 | 0% | 0 | 0 / 0 |
muscle | 40% | 348.77 | 320 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 8% | 0.20 | 6 / 80 |
spleen | 5% | 32.54 | 11 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.09 | 1 / 29 |
peripheral blood | 0% | 1.32 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006915 | Biological process | apoptotic process |
GO_0070534 | Biological process | protein K63-linked ubiquitination |
GO_0016567 | Biological process | protein ubiquitination |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0006513 | Biological process | protein monoubiquitination |
GO_0010508 | Biological process | positive regulation of autophagy |
GO_1904262 | Biological process | negative regulation of TORC1 signaling |
GO_0034198 | Biological process | cellular response to amino acid starvation |
GO_0005764 | Cellular component | lysosome |
GO_0031090 | Cellular component | organelle membrane |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | RNF152 |
Protein name | RING-type E3 ubiquitin transferase (EC 2.3.2.27) E3 ubiquitin-protein ligase RNF152 (EC 2.3.2.27) (RING finger protein 152) (RING-type E3 ubiquitin transferase RNF152) |
Synonyms | |
Description | FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB . Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling . Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition . Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation . Induces apoptosis when overexpressed . . |
Accessions | ENST00000591306.5 ENST00000312828.4 K7EMG3 Q8N8N0 |