PAEP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PAEP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PAEP at tissue level.

III. Associated gene sets

GO_2000359Biological processregulation of binding of sperm to zona pellucida
GO_0006915Biological processapoptotic process
GO_0032725Biological processpositive regulation of granulocyte macrophage colony-stimulating factor production
GO_1902491Biological processnegative regulation of sperm capacitation
GO_0005576Cellular componentextracellular region
GO_0005515Molecular functionprotein binding
GO_0036094Molecular functionsmall molecule binding

IV. Literature review

[source]
Gene namePAEP
Protein nameGlycodelin (GD) (Placental protein 14) (PP14) (Pregnancy-associated endometrial alpha-2 globulin) (PAEG) (PEG) (Progestagen-associated endometrial protein) (Progesterone-associated endometrial protein) (Zona-binding inhibitory factor-1) (ZIF-1)
Progestagen associated endometrial protein
Glycodelin (Progestagen associated endometrial protein)
Synonyms
DescriptionFUNCTION: Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities . Glycodelin-C stimulates binding of spermatozoa to the zona pellucida . Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa . Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa . .

AccessionsENST00000371768.7
H0Y530
ENST00000418284.5
A6XNE0
ENST00000371766.6 [P09466-1]
H0Y4U4
F2Z349
ENST00000433563.5
H0Y6A4
ENST00000454923.5
Q5T6T6
ENST00000611414.4
ENST00000277508.9 [P09466-1]
ENST00000457014.1
P09466
ENST00000479141.6 [P09466-1]