BRMS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0090312Biological processpositive regulation of protein deacetylation
GO_0030336Biological processnegative regulation of cell migration
GO_1902455Biological processnegative regulation of stem cell population maintenance
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0042981Biological processregulation of apoptotic process
GO_2000210Biological processpositive regulation of anoikis
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0070822Cellular componentSin3-type complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0051059Molecular functionNF-kappaB binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameBRMS1
Protein nameBRMS1 transcriptional repressor and anoikis regulator (Breast cancer metastasis suppressor 1, isoform CRA_c)
BRMS1 transcriptional repressor and anoikis regulator
Breast cancer metastasis-suppressor 1
SynonymshCG_20309
DescriptionFUNCTION: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. .

AccessionsENST00000524699.5
E9PPD1
H0YCF7
Q9HCU9
G5E9I4
ENST00000527375.5
E9PJF5
ENST00000359957.8
ENST00000530756.1
ENST00000425825.6